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Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity.
Guimarães MA, de Oliveira RN, de Almeida RL, Mafud AC, Sarkis ALV, Ganassin R, da Silva MP, Roquini DB, Veras LM, Sawada TCH, Ropke CD, Muehlmann LA, Joanitti GA, Kuckelhaus SAS, Allegretti SM, Mascarenhas YP, de Moraes J, Leite JRSA. Guimarães MA, et al. Among authors: mafud ac. PLoS One. 2018 May 11;13(5):e0196667. doi: 10.1371/journal.pone.0196667. eCollection 2018. PLoS One. 2018. PMID: 29750792 Free PMC article.
Structure⁻Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian Cells.
Campelo Y, Ombredane A, Vasconcelos AG, Albuquerque L, Moreira DC, Plácido A, Rocha J, Hilarion Fokoue H, Yamaguchi L, Mafud A, Mascarenhas YP, Delerue-Matos C, Borges T, Joanitti GA, Arcanjo D, Kato MJ, Kuckelhaus SAS, Silva MPN, Moraes J, Leite JRSA. Campelo Y, et al. Int J Mol Sci. 2018 Jun 19;19(6):1802. doi: 10.3390/ijms19061802. Int J Mol Sci. 2018. PMID: 29921756 Free PMC article.
Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine.
de Lima LI, Py-Daniel KR, Guimarães MA, Muehlmann LA, Mafud AC, Mascarenhas YP, Moraes J, de Souza de Almeida Leite JR, Jiang CS, Azevedo RB, Figueiró Longo JP. de Lima LI, et al. Among authors: mafud ac. Nanomedicine (Lond). 2018 Apr 1;13(7):689-702. doi: 10.2217/nnm-2017-0308. Epub 2018 Mar 22. Nanomedicine (Lond). 2018. PMID: 29564947
Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni.
Guimarães MA, de Oliveira RN, Véras LM, Lima DF, Campelo YD, Campos SA, Kuckelhaus SA, Pinto PL, Eaton P, Mafud AC, Mascarenhas YP, Allegretti SM, de Moraes J, Lolić A, Verbić T, Leite JR. Guimarães MA, et al. Among authors: mafud ac. PLoS Negl Trop Dis. 2015 Mar 27;9(3):e0003656. doi: 10.1371/journal.pntd.0003656. eCollection 2015 Mar. PLoS Negl Trop Dis. 2015. PMID: 25816129 Free PMC article.
Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves.
Rocha JA, Andrade IM, Véras LM, Quelemes PV, Lima DF, Soares MJ, Pinto PL, Mayo SJ, Ivanova G, Rangel M, Correia M, Mafud AC, Mascarenhas YP, Delerue-Matos C, de Moraes J, Eaton P, Leite JR. Rocha JA, et al. Among authors: mafud ac. Phytother Res. 2017 Apr;31(4):624-630. doi: 10.1002/ptr.5771. Epub 2017 Jan 23. Phytother Res. 2017. PMID: 28111828
Synergistic effects of in vitro combinations of piplartine, epiisopiloturine and praziquantel against Schistosoma mansoni.
Campelo YDM, Mafud AC, Véras LMC, Guimarães MA, Yamaguchi LF, Lima DF, Arcanjo DDR, Kato MJ, Mendonça RZ, Pinto PLS, Mascarenhas YP, Silva MPN, de Moraes J, Eaton P, de Souza de Almeida Leite JR. Campelo YDM, et al. Among authors: mafud ac. Biomed Pharmacother. 2017 Apr;88:488-499. doi: 10.1016/j.biopha.2016.12.057. Epub 2017 Jan 23. Biomed Pharmacother. 2017. PMID: 28126674
31 results