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GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141.
Naesens L, Muppala S, Acharya D, Nemegeer J, Bogaert D, Lee JH, Staes K, Debacker V, De Bleser P, De Bruyne M, De Baere E, van Gent M, Liu G, Lambrecht BN, Staal J, Kerre T, Beyaert R, Maelfait J, Tavernier SJ, Gack MU, Haerynck F. Naesens L, et al. Among authors: maelfait j. Sci Immunol. 2022 Nov 25;7(77):eabq4531. doi: 10.1126/sciimmunol.abq4531. Epub 2022 Nov 18. Sci Immunol. 2022. PMID: 36399538 Free PMC article.
Non-apoptotic functions of caspase-8.
Maelfait J, Beyaert R. Maelfait J, et al. Biochem Pharmacol. 2008 Dec 1;76(11):1365-73. doi: 10.1016/j.bcp.2008.07.034. Epub 2008 Aug 6. Biochem Pharmacol. 2008. PMID: 18761323 Review.
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Mc Guire C, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G. Matmati M, et al. Among authors: maelfait j. Nat Genet. 2011 Aug 14;43(9):908-12. doi: 10.1038/ng.874. Nat Genet. 2011. PMID: 21841782
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.
Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs MJ, Willart M, Ibañez LI, Hammad H, Lambrecht BN, Beyaert R, Saelens X, van Loo G. Maelfait J, et al. PLoS Pathog. 2016 Jan 27;12(1):e1005410. doi: 10.1371/journal.ppat.1005410. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26815999 Free PMC article.
49 results