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PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity.
Nat Immunol. 2022 Mar;23(3):399-410. doi: 10.1038/s41590-021-01125-7. Epub 2022 Feb 10.
Nat Immunol. 2022.
PMID: 35145298
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.
Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, Okazaki T.
Maruhashi T, et al. Among authors: maeda tk.
Nat Immunol. 2018 Dec;19(12):1415-1426. doi: 10.1038/s41590-018-0217-9. Epub 2018 Oct 22.
Nat Immunol. 2018.
PMID: 30349037
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Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.
Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, Okazaki T.
Sugiura D, et al. Among authors: maeda tk.
Science. 2019 May 10;364(6440):558-566. doi: 10.1126/science.aav7062. Epub 2019 Apr 18.
Science. 2019.
PMID: 31000591
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Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.
Maruhashi T, Sugiura D, Okazaki IM, Shimizu K, Maeda TK, Ikubo J, Yoshikawa H, Maenaka K, Ishimaru N, Kosako H, Takemoto T, Okazaki T.
Maruhashi T, et al. Among authors: maeda tk.
Immunity. 2022 May 10;55(5):912-924.e8. doi: 10.1016/j.immuni.2022.03.013. Epub 2022 Apr 11.
Immunity. 2022.
PMID: 35413245
Free article.
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Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.
Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, Okazaki T.
Maeda TK, et al.
J Biol Chem. 2019 Apr 12;294(15):6017-6026. doi: 10.1074/jbc.RA119.007455. Epub 2019 Feb 13.
J Biol Chem. 2019.
PMID: 30760527
Free PMC article.
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