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Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, Rønn LC, Gether U. Thorsen TS, et al. Among authors: madsen kl. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. doi: 10.1073/pnas.0902225107. Epub 2009 Dec 14. Proc Natl Acad Sci U S A. 2010. PMID: 20018661 Free PMC article.
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.
Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Bach A, et al. Among authors: madsen kl. Org Biomol Chem. 2010 Oct 7;8(19):4281-8. doi: 10.1039/c0ob00025f. Epub 2010 Jul 29. Org Biomol Chem. 2010. PMID: 20668766 Free PMC article.
Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.
Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, Arleth L, Madsen KL. Karlsen ML, et al. Among authors: madsen kl. Structure. 2015 Jul 7;23(7):1258-1270. doi: 10.1016/j.str.2015.04.020. Epub 2015 Jun 11. Structure. 2015. PMID: 26073603 Free PMC article.
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
Christensen NR, De Luca M, Lever MB, Richner M, Hansen AB, Noes-Holt G, Jensen KL, Rathje M, Jensen DB, Erlendsson S, Bartling CR, Ammendrup-Johnsen I, Pedersen SE, Schönauer M, Nissen KB, Midtgaard SR, Teilum K, Arleth L, Sørensen AT, Bach A, Strømgaard K, Meehan CF, Vaegter CB, Gether U, Madsen KL. Christensen NR, et al. Among authors: madsen kl. EMBO Mol Med. 2020 Jun 8;12(6):e11248. doi: 10.15252/emmm.201911248. Epub 2020 Apr 30. EMBO Mol Med. 2020. PMID: 32352640 Free PMC article.
211 results