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RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Lara Ordónez AJ, Fernández B, Fdez E, Romo-Lozano M, Madero-Pérez J, Lobbestael E, Baekelandt V, Aiastui A, López de Munaín A, Melrose HL, Civiero L, Hilfiker S. Lara Ordónez AJ, et al. Among authors: madero perez j. Hum Mol Genet. 2019 Nov 1;28(21):3552-3568. doi: 10.1093/hmg/ddz201. Hum Mol Genet. 2019. PMID: 31428781 Free PMC article.
LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.
Blanca Ramírez M, Madero-Perez J, Rivero-Rios P, Martinez-Salvador M, Lara Ordonez AJ, Fernandez B, Fdez E, Hilfiker S. Blanca Ramírez M, et al. Curr Protein Pept Sci. 2017;18(7):677-686. doi: 10.2174/1389203717666160311121748. Curr Protein Pept Sci. 2017. PMID: 26965688 Review.
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Madero-Pérez J, Gonnelli A, Drouyer M, Chartier-Harlin MC, Taymans JM, Bubacco L, Greggio E, Hilfiker S. Blanca Ramírez M, et al. Among authors: madero perez j. Hum Mol Genet. 2017 Jul 15;26(14):2747-2767. doi: 10.1093/hmg/ddx161. Hum Mol Genet. 2017. PMID: 28453723 Free PMC article.
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.
Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S. Madero-Pérez J, et al. Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y. Mol Neurodegener. 2018. PMID: 29357897 Free PMC article.
Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease.
Gómez-Suaga P, Fdez E, Fernández B, Martínez-Salvador M, Blanca Ramírez M, Madero-Pérez J, Rivero-Ríos P, Fuentes JM, Hilfiker S. Gómez-Suaga P, et al. Neuropharmacology. 2014 Oct;85:45-56. doi: 10.1016/j.neuropharm.2014.05.020. Epub 2014 May 24. Neuropharmacology. 2014. PMID: 24863040 Review.
15 results