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Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.
Hassin O, Nataraj NB, Shreberk-Shaked M, Aylon Y, Yaeger R, Fontemaggi G, Mukherjee S, Maddalena M, Avioz A, Iancu O, Mallel G, Gershoni A, Grosheva I, Feldmesser E, Ben-Dor S, Golani O, Hendel A, Blandino G, Kelsen D, Yarden Y, Oren M. Hassin O, et al. Among authors: maddalena m. Nat Commun. 2022 May 19;13(1):2800. doi: 10.1038/s41467-022-30481-7. Nat Commun. 2022. PMID: 35589715 Free PMC article.
TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment.
Maddalena M, Mallel G, Nataraj NB, Shreberk-Shaked M, Hassin O, Mukherjee S, Arandkar S, Rotkopf R, Kapsack A, Lambiase G, Pellegrino B, Ben-Isaac E, Golani O, Addadi Y, Hajaj E, Eilam R, Straussman R, Yarden Y, Lotem M, Oren M. Maddalena M, et al. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2025631118. doi: 10.1073/pnas.2025631118. Proc Natl Acad Sci U S A. 2021. PMID: 34088837 Free PMC article.
Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins.
Mukherjee S, Maddalena M, Lü Y, Martinez S, Nataraj NB, Noronha A, Sinha S, Teng K, Cohen-Kaplan V, Ziv T, Arandkar S, Hassin O, Chatterjee R, Pirona AC, Shreberk-Shaked M, Gershoni A, Aylon Y, Elazar Z, Yarden Y, Schramek D, Oren M. Mukherjee S, et al. Among authors: maddalena m. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2119644119. doi: 10.1073/pnas.2119644119. Epub 2022 Apr 19. Proc Natl Acad Sci U S A. 2022. PMID: 35439056 Free PMC article.
Inhibition of MRN activity by a telomere protein motif.
Khayat F, Cannavo E, Alshmery M, Foster WR, Chahwan C, Maddalena M, Smith C, Oliver AW, Watson AT, Carr AM, Cejka P, Bianchi A. Khayat F, et al. Among authors: maddalena m. Nat Commun. 2021 Jun 22;12(1):3856. doi: 10.1038/s41467-021-24047-2. Nat Commun. 2021. PMID: 34158470 Free PMC article.
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells.
Brina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D'Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, Lauria F, Parhizgari N, Valdata A, Maddalena M, Calcinotto A, Bolis M, Rinaldi A, Barry S, Rüschoff JH, Sabbadin M, Sumanasuriya S, Crespo M, Sharp A, Yuan W, Grinu M, Boyle A, Miller C, Trotman L, Delaleu N, Fassan M, Moch H, Viero G, de Bono J, Alimonti A. Brina D, et al. Among authors: maddalena m. Nat Cancer. 2023 Aug;4(8):1102-1121. doi: 10.1038/s43018-023-00594-z. Epub 2023 Jul 17. Nat Cancer. 2023. PMID: 37460872
Jumping from Fragment to Drug via Smart Scaffolds.
Farahani MD, França TCC, Alapour S, Shahout F, Boulon R, Iddir M, Maddalena M, Ayotte Y, LaPlante SR. Farahani MD, et al. Among authors: maddalena m. ChemMedChem. 2022 May 18;17(10):e202200092. doi: 10.1002/cmdc.202200092. Epub 2022 Apr 1. ChemMedChem. 2022. PMID: 35298873
An optimized design of a parallel robot for gait training.
Maddalena M, Saadat M, Rastegarpanah A, Loureiro RCV. Maddalena M, et al. IEEE Int Conf Rehabil Robot. 2017 Jul;2017:418-423. doi: 10.1109/ICORR.2017.8009283. IEEE Int Conf Rehabil Robot. 2017. PMID: 28813855
22 results