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The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
Madan E, Parker TM, Bauer MR, Dhiman A, Pelham CJ, Nagane M, Kuppusamy ML, Holmes M, Holmes TR, Shaik K, Shee K, Kiparoidze S, Smith SD, Park YA, Gomm JJ, Jones LJ, Tomás AR, Cunha AC, Selvendiran K, Hansen LA, Fersht AR, Hideg K, Gogna R, Kuppusamy P. Madan E, et al. J Biol Chem. 2018 Mar 23;293(12):4262-4276. doi: 10.1074/jbc.RA117.000950. Epub 2018 Jan 30. J Biol Chem. 2018. PMID: 29382728 Free PMC article.
Flower isoforms promote competitive growth in cancer.
Madan E, Pelham CJ, Nagane M, Parker TM, Canas-Marques R, Fazio K, Shaik K, Yuan Y, Henriques V, Galzerano A, Yamashita T, Pinto MAF, Palma AM, Camacho D, Vieira A, Soldini D, Nakshatri H, Post SR, Rhiner C, Yamashita H, Accardi D, Hansen LA, Carvalho C, Beltran AL, Kuppusamy P, Gogna R, Moreno E. Madan E, et al. Nature. 2019 Aug;572(7768):260-264. doi: 10.1038/s41586-019-1429-3. Epub 2019 Jul 24. Nature. 2019. PMID: 31341286
HIF-transcribed p53 chaperones HIF-1α.
Madan E, Parker TM, Pelham CJ, Palma AM, Peixoto ML, Nagane M, Chandaria A, Tomás AR, Canas-Marques R, Henriques V, Galzerano A, Cabral-Teixeira J, Selvendiran K, Kuppusamy P, Carvalho C, Beltran A, Moreno E, Pati UK, Gogna R. Madan E, et al. Nucleic Acids Res. 2019 Nov 4;47(19):10212-10234. doi: 10.1093/nar/gkz766. Nucleic Acids Res. 2019. PMID: 31538203 Free PMC article.
Cell Competition Spurs Selection of Aggressive Cancer Cells.
Parker T, Madan E, Gupta K, Moreno E, Gogna R. Parker T, et al. Among authors: madan e. Trends Cancer. 2020 Sep;6(9):732-736. doi: 10.1016/j.trecan.2020.03.008. Epub 2020 Apr 20. Trends Cancer. 2020. PMID: 32327348
Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer.
Madan E, Peixoto ML, Dimitrion P, Eubank TD, Yekelchyk M, Talukdar S, Fisher PB, Mi QS, Moreno E, Gogna R. Madan E, et al. Trends Cell Biol. 2020 Dec;30(12):967-978. doi: 10.1016/j.tcb.2020.10.002. Epub 2020 Nov 4. Trends Cell Biol. 2020. PMID: 33160818 Review.
Cell competition in intratumoral and tumor microenvironment interactions.
Parker TM, Gupta K, Palma AM, Yekelchyk M, Fisher PB, Grossman SR, Won KJ, Madan E, Moreno E, Gogna R. Parker TM, et al. Among authors: madan e. EMBO J. 2021 Sep 1;40(17):e107271. doi: 10.15252/embj.2020107271. Epub 2021 Aug 9. EMBO J. 2021. PMID: 34368984 Free PMC article. Review.
Flower lose, a cell fitness marker, predicts COVID-19 prognosis.
Yekelchyk M, Madan E, Wilhelm J, Short KR, Palma AM, Liao L, Camacho D, Nkadori E, Winters MT, Rice ES, Rolim I, Cruz-Duarte R, Pelham CJ, Nagane M, Gupta K, Chaudhary S, Braun T, Pillappa R, Parker MS, Menter T, Matter M, Haslbauer JD, Tolnay M, Galior KD, Matkwoskyj KA, McGregor SM, Muller LK, Rakha EA, Lopez-Beltran A, Drapkin R, Ackermann M, Fisher PB, Grossman SR, Godwin AK, Kulasinghe A, Martinez I, Marsh CB, Tang B, Wicha MS, Won KJ, Tzankov A, Moreno E, Gogna R. Yekelchyk M, et al. Among authors: madan e. EMBO Mol Med. 2021 Nov 8;13(11):e13714. doi: 10.15252/emmm.202013714. Epub 2021 Oct 18. EMBO Mol Med. 2021. PMID: 34661368 Free PMC article.
Cell Competition in Carcinogenesis.
Madan E, Palma AM, Vudatha V, Trevino JG, Natarajan KN, Winn RA, Won KJ, Graham TA, Drapkin R, McDonald SAC, Fisher PB, Gogna R. Madan E, et al. Cancer Res. 2022 Dec 16;82(24):4487-4496. doi: 10.1158/0008-5472.CAN-22-2217. Cancer Res. 2022. PMID: 36214625 Free PMC article.
88 results