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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates.
Pharmaceutics. 2021 Aug 24;13(9):1325. doi: 10.3390/pharmaceutics13091325.
Pharmaceutics. 2021.
PMID: 34575401
Free PMC article.
Review.
Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol.
Macwan JS, Fraczkiewicz G, Bertolino M, Krüger P, Peters SA.
Macwan JS, et al.
CPT Pharmacometrics Syst Pharmacol. 2021 Jun;10(6):622-632. doi: 10.1002/psp4.12634. Epub 2021 Jun 3.
CPT Pharmacometrics Syst Pharmacol. 2021.
PMID: 34080804
Free PMC article.
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The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping.
Bolger MB, Macwan JS, Sarfraz M, Almukainzi M, Löbenberg R.
Bolger MB, et al. Among authors: macwan js.
J Pharm Sci. 2019 Jan;108(1):268-278. doi: 10.1016/j.xphs.2018.09.036. Epub 2018 Oct 11.
J Pharm Sci. 2019.
PMID: 30316900
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Diabetes mellitus reduces the clearance of atorvastatin lactone: results of a population pharmacokinetic analysis in renal transplant recipients and in vitro studies using human liver microsomes.
Dostalek M, Sam WJ, Paryani KR, Macwan JS, Gohh RY, Akhlaghi F.
Dostalek M, et al. Among authors: macwan js.
Clin Pharmacokinet. 2012 Sep 1;51(9):591-606. doi: 10.2165/11632690-000000000-00000.
Clin Pharmacokinet. 2012.
PMID: 22775412
Clinical Trial.
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Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Macwan JS, Ionita IA, Dostalek M, Akhlaghi F.
Macwan JS, et al.
Anal Bioanal Chem. 2011 Apr;400(2):423-33. doi: 10.1007/s00216-011-4804-y. Epub 2011 Feb 26.
Anal Bioanal Chem. 2011.
PMID: 21359569
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Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry.
Dostalek M, Macwan JS, Chitnis SD, Ionita IA, Akhlaghi F.
Dostalek M, et al. Among authors: macwan js.
J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 1;878(19):1629-33. doi: 10.1016/j.jchromb.2010.04.001. Epub 2010 Apr 10.
J Chromatogr B Analyt Technol Biomed Life Sci. 2010.
PMID: 20434409
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A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Macwan JS, Ionita IA, Akhlaghi F.
Macwan JS, et al.
Anal Bioanal Chem. 2012 Jan;402(3):1217-27. doi: 10.1007/s00216-011-5548-4. Epub 2011 Nov 23.
Anal Bioanal Chem. 2012.
PMID: 22108655
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