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Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer.
Kleiblova P, Stolarova L, Krizova K, Lhota F, Hojny J, Zemankova P, Havranek O, Vocka M, Cerna M, Lhotova K, Borecka M, Janatova M, Soukupova J, Sevcik J, Zimovjanova M, Kotlas J, Panczak A, Vesela K, Cervenkova J, Schneiderova M, Burocziova M, Burdova K, Stranecky V, Foretova L, Machackova E, Tavandzis S, Kmoch S, Macurek L, Kleibl Z. Kleiblova P, et al. Among authors: macurek l. Int J Cancer. 2019 Oct 1;145(7):1782-1797. doi: 10.1002/ijc.32385. Epub 2019 May 20. Int J Cancer. 2019. PMID: 31050813 Free article.
Expression of human BRCA1Δ17-19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response.
Sevcik J, Falk M, Macurek L, Kleiblova P, Lhota F, Hojny J, Stefancikova L, Janatova M, Bartek J, Stribrna J, Hodny Z, Jezkova L, Pohlreich P, Kleibl Z. Sevcik J, et al. Among authors: macurek l. Cell Signal. 2013 May;25(5):1186-93. doi: 10.1016/j.cellsig.2013.02.008. Epub 2013 Feb 14. Cell Signal. 2013. PMID: 23416467
Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.
Kleiblova P, Shaltiel IA, Benada J, Ševčík J, Pecháčková S, Pohlreich P, Voest EE, Dundr P, Bartek J, Kleibl Z, Medema RH, Macurek L. Kleiblova P, et al. Among authors: macurek l. J Cell Biol. 2013 May 13;201(4):511-21. doi: 10.1083/jcb.201210031. Epub 2013 May 6. J Cell Biol. 2013. PMID: 23649806 Free PMC article.
Residual Cdk1/2 activity after DNA damage promotes senescence.
Müllers E, Silva Cascales H, Burdova K, Macurek L, Lindqvist A. Müllers E, et al. Among authors: macurek l. Aging Cell. 2017 Jun;16(3):575-584. doi: 10.1111/acel.12588. Epub 2017 Mar 26. Aging Cell. 2017. PMID: 28345297 Free PMC article.
MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.
von Morgen P, Burdova K, Flower TG, O'Reilly NJ, Boulton SJ, Smerdon SJ, Macurek L, Hořejší Z. von Morgen P, et al. Among authors: macurek l. Oncogene. 2017 Aug 24;36(34):4943-4950. doi: 10.1038/onc.2017.99. Epub 2017 Apr 24. Oncogene. 2017. PMID: 28436950 Free PMC article.
WIP1 phosphatase as pharmacological target in cancer therapy.
Pecháčková S, Burdová K, Macurek L. Pecháčková S, et al. Among authors: macurek l. J Mol Med (Berl). 2017 Jun;95(6):589-599. doi: 10.1007/s00109-017-1536-2. Epub 2017 Apr 24. J Mol Med (Berl). 2017. PMID: 28439615 Free PMC article. Review.
Germline CHEK2 Gene Mutations in Hereditary Breast Cancer Predisposition - Mutation Types and their Biological and Clinical Relevance.
Kleiblová P, Stolařová L, Křížová K, Lhota F, Hojný J, Zemánková P, Havránek O, Vočka M, Černá M, Lhotová K, Borecká M, Janatová M, Soukupová J, Ševčík J, Zimovjanová M, Kotlas J, Panczak A, Veselá K, Červenková J, Schneiderová M, Burócziová M, Burdová K, Stránecký V, Foretová L, Macháčková E, Tavandzis S, Kmoch S, Macůrek L, Kleibl Z. Kleiblová P, et al. Among authors: macurek l. Klin Onkol. 2019 Summer;32(Supplementum2):36-50. doi: 10.14735/amko2019S36. Klin Onkol. 2019. PMID: 31409080 English.
60 results