Macklin TK - Search Results

1

Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor.

Jeso V, Cherry L, Macklin TK, Pan SC, LoGrasso PV, Micalizio GC. Jeso V, et al. Among authors: macklin tk. Org Lett. 2011 Oct 7;13(19):5108-11. doi: 10.1021/ol2019828. Epub 2011 Aug 25. Org Lett. 2011. PMID: 21866939

2

Total synthesis and structure elucidation of (+)-phorbasin C.

Macklin TK, Micalizio GC. Macklin TK, et al. J Am Chem Soc. 2009 Feb 4;131(4):1392-3. doi: 10.1021/ja809491b. J Am Chem Soc. 2009. PMID: 19173665

3

Convergent and stereospecific synthesis of complex skipped polyenes and polyunsaturated fatty acids.

Macklin TK, Micalizio GC. Macklin TK, et al. Nat Chem. 2010 Aug;2(8):638-43. doi: 10.1038/nchem.665. Epub 2010 May 23. Nat Chem. 2010. PMID: 20651725 Free PMC article.

4

Directed ortho metalation methodology. The N,N-dialkyl aryl O-sulfamate as a new directed metalation group and cross-coupling partner for Grignard reagents.

Macklin TK, Snieckus V. Macklin TK, et al. Org Lett. 2005 Jun 23;7(13):2519-22. doi: 10.1021/ol050393c. Org Lett. 2005. PMID: 15957880

5

Directed ortho metalation-cross coupling strategies. N-cumyl arylsulfonamides. Facile deprotection and expedient route to 7- and 4,7-substituted saccharins.

Blanchet J, Macklin T, Ang P, Metallinos C, Snieckus V. Blanchet J, et al. J Org Chem. 2007 Apr 27;72(9):3199-206. doi: 10.1021/jo062385v. Epub 2007 Mar 27. J Org Chem. 2007. PMID: 17385915

6

Carbamoyl translocations by an anionic ortho-fries and cumulenolate alpha-acylation pathway: regioselective synthesis of polysubstituted chromone 3- and 8-carboxamides.

Macklin TK, Panteleev J, Snieckus V. Macklin TK, et al. Angew Chem Int Ed Engl. 2008;47(11):2097-101. doi: 10.1002/anie.200704360. Angew Chem Int Ed Engl. 2008. PMID: 18266267 No abstract available.

7

Iridium-catalyzed C-H activation versus directed ortho metalation: complementary borylation of aromatics and heteroaromatics.

Hurst TE, Macklin TK, Becker M, Hartmann E, Kügel W, Parisienne-La Salle JC, Batsanov AS, Marder TB, Snieckus V. Hurst TE, et al. Among authors: macklin tk. Chemistry. 2010 Jul 19;16(27):8155-61. doi: 10.1002/chem.201000401. Chemistry. 2010. PMID: 20533457

8

First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate.

Sun H, Monenschein H, Schiffer HH, Reichard HA, Kikuchi S, Hopkins M, Macklin TK, Hitchcock S, Adams M, Green J, Brown J, Murphy ST, Kaushal N, Collia DR, Moore S, Ray WJ, English NM, Carlton MBL, Brice NL. Sun H, et al. Among authors: macklin tk. J Med Chem. 2021 Jul 22;64(14):9875-9890. doi: 10.1021/acs.jmedchem.0c02081. Epub 2021 Apr 16. J Med Chem. 2021. PMID: 33861086

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