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Combinatorial expression of GPCR isoforms affects signalling and drug responses.
Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J, Tobin AB, Ladds G, Milligan G, Gloriam DE, Puthenveedu MA, Babu MM. Marti-Solano M, et al. Among authors: mackenzie ae. Nature. 2020 Nov;587(7835):650-656. doi: 10.1038/s41586-020-2888-2. Epub 2020 Nov 4. Nature. 2020. PMID: 33149304 Free PMC article.
G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes.
Lin LC, Quon T, Engberg S, Mackenzie AE, Tobin AB, Milligan G. Lin LC, et al. Among authors: mackenzie ae. ACS Pharmacol Transl Sci. 2021 Nov 30;4(6):1835-1848. doi: 10.1021/acsptsci.1c00224. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927014 Free PMC article.
The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G. Hudson BD, et al. Among authors: mackenzie ae. Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26. Mol Pharmacol. 2013. PMID: 23979972 Free PMC article.
Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35.
Binti Mohd Amir NAS, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE. Binti Mohd Amir NAS, et al. Among authors: mackenzie ae. J Immunol. 2018 Jul 15;201(2):714-724. doi: 10.4049/jimmunol.1700884. Epub 2018 Jun 6. J Immunol. 2018. PMID: 29875152 Free PMC article.
115 results