Mackay S - Search Results

1

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial.

Spiegel JY, Patel S, Muffly L, Hossain NM, Oak J, Baird JH, Frank MJ, Shiraz P, Sahaf B, Craig J, Iglesias M, Younes S, Natkunam Y, Ozawa MG, Yang E, Tamaresis J, Chinnasamy H, Ehlinger Z, Reynolds W, Lynn R, Rotiroti MC, Gkitsas N, Arai S, Johnston L, Lowsky R, Majzner RG, Meyer E, Negrin RS, Rezvani AR, Sidana S, Shizuru J, Weng WK, Mullins C, Jacob A, Kirsch I, Bazzano M, Zhou J, Mackay S, Bornheimer SJ, Schultz L, Ramakrishna S, Davis KL, Kong KA, Shah NN, Qin H, Fry T, Feldman S, Mackall CL, Miklos DB. Spiegel JY, et al. Among authors: mackay s. Nat Med. 2021 Aug;27(8):1419-1431. doi: 10.1038/s41591-021-01436-0. Epub 2021 Jul 26. Nat Med. 2021. PMID: 34312556 Free PMC article. Clinical Trial.

2

Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response.

Xue Q, Bettini E, Paczkowski P, Ng C, Kaiser A, McConnell T, Kodrasi O, Quigley MF, Heath J, Fan R, Mackay S, Dudley ME, Kassim SH, Zhou J. Xue Q, et al. Among authors: mackay s. J Immunother Cancer. 2017 Nov 21;5(1):85. doi: 10.1186/s40425-017-0293-7. J Immunother Cancer. 2017. PMID: 29157295 Free PMC article.

3

Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL.

Rossi J, Paczkowski P, Shen YW, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, Bot A. Rossi J, et al. Among authors: mackay s. Blood. 2018 Aug 23;132(8):804-814. doi: 10.1182/blood-2018-01-828343. Epub 2018 Jun 12. Blood. 2018. PMID: 29895668 Free PMC article. Clinical Trial.

4

BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer.

Lu L, Huang H, Zhou J, Ma W, Mackay S, Wang Z. Lu L, et al. Among authors: mackay s. BMC Cancer. 2019 Apr 25;19(1):387. doi: 10.1186/s12885-019-5595-3. BMC Cancer. 2019. PMID: 31023256 Free PMC article.

5

Single-Cell Multiplexed Proteomics on the IsoLight Resolves Cellular Functional Heterogeneity to Reveal Clinical Responses of Cancer Patients to Immunotherapies.

Liu D, Paczkowski P, Mackay S, Ng C, Zhou J. Liu D, et al. Among authors: mackay s. Methods Mol Biol. 2020;2055:413-431. doi: 10.1007/978-1-4939-9773-2_19. Methods Mol Biol. 2020. PMID: 31502163

6

Complement-activated human endothelial cells stimulate increased polyfunctionality in alloreactive T cells.

Xie CB, Zhou J, Mackay S, Pober JS. Xie CB, et al. Among authors: mackay s. Am J Transplant. 2021 May;21(5):1902-1909. doi: 10.1111/ajt.16485. Epub 2021 Feb 1. Am J Transplant. 2021. PMID: 33415805 Free PMC article.

7

Applying single-cell highly multiplexed secretome proteomics to characterize immunotherapeutic products and predict clinical responses.

Ni W, Han EX, Cyr M, Mackay S, Zhou J. Ni W, et al. Among authors: mackay s. Proteomics. 2023 Jul;23(13-14):e2200242. doi: 10.1002/pmic.202200242. Epub 2023 Feb 25. Proteomics. 2023. PMID: 36786585 Review.

8

The IgG4 hinge with CD28 transmembrane domain improves V_HH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer.

Li N, Quan A, Li D, Pan J, Ren H, Hoeltzel G, de Val N, Ashworth D, Ni W, Zhou J, Mackay S, Hewitt SM, Cachau R, Ho M. Li N, et al. Among authors: mackay s. Nat Commun. 2023 Apr 8;14(1):1986. doi: 10.1038/s41467-023-37616-4. Nat Commun. 2023. PMID: 37031249 Free PMC article.

9

A Phase I/II Trial of HER2 Vaccine-Primed Autologous T-Cell Infusions in Patients with Treatment Refractory HER2-Overexpressing Breast Cancer.

Disis ML, Dang Y, Coveler AL, Childs JS, Higgins DM, Liu Y, Zhou J, Mackay S, Salazar LG. Disis ML, et al. Among authors: mackay s. Clin Cancer Res. 2023 Sep 1;29(17):3362-3371. doi: 10.1158/1078-0432.CCR-22-3578. Clin Cancer Res. 2023. PMID: 37093223 Free PMC article.

10

Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours.

Li D, Wang R, Liang T, Ren H, Park C, Tai CH, Ni W, Zhou J, Mackay S, Edmondson E, Khan J, Croix BS, Ho M. Li D, et al. Among authors: mackay s. Nat Commun. 2023 Sep 22;14(1):5920. doi: 10.1038/s41467-023-41631-w. Nat Commun. 2023. PMID: 37739951 Free PMC article.

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