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Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.
Kaye DM, Shihata WA, Jama HA, Tsyganov K, Ziemann M, Kiriazis H, Horlock D, Vijay A, Giam B, Vinh A, Johnson C, Fiedler A, Donner D, Snelson M, Coughlan MT, Phillips S, Du XJ, El-Osta A, Drummond G, Lambert GW, Spector TD, Valdes AM, Mackay CR, Marques FZ. Kaye DM, et al. Among authors: mackay cr. Circulation. 2020 Apr 28;141(17):1393-1403. doi: 10.1161/CIRCULATIONAHA.119.043081. Epub 2020 Feb 25. Circulation. 2020. PMID: 32093510
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.
Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR. Macia L, et al. Among authors: mackay cr. Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734. Nat Commun. 2015. PMID: 25828455 Free article.
High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.
Marques FZ, Nelson E, Chu PY, Horlock D, Fiedler A, Ziemann M, Tan JK, Kuruppu S, Rajapakse NW, El-Osta A, Mackay CR, Kaye DM. Marques FZ, et al. Among authors: mackay cr. Circulation. 2017 Mar 7;135(10):964-977. doi: 10.1161/CIRCULATIONAHA.116.024545. Epub 2016 Dec 7. Circulation. 2017. PMID: 27927713
Gut-derived acetate promotes B10 cells with antiinflammatory effects.
Daïen CI, Tan J, Audo R, Mielle J, Quek LE, Krycer JR, Angelatos A, Duraes M, Pinget G, Ni D, Robert R, Alam MJ, Amian MCB, Sierro F, Parmar A, Perkins G, Hoque S, Gosby AK, Simpson SJ, Ribeiro RV, Mackay CR, Macia L. Daïen CI, et al. Among authors: mackay cr. JCI Insight. 2021 Apr 8;6(7):e144156. doi: 10.1172/jci.insight.144156. JCI Insight. 2021. PMID: 33729999 Free PMC article.
Processed foods drive intestinal barrier permeability and microvascular diseases.
Snelson M, Tan SM, Clarke RE, de Pasquale C, Thallas-Bonke V, Nguyen TV, Penfold SA, Harcourt BE, Sourris KC, Lindblom RS, Ziemann M, Steer D, El-Osta A, Davies MJ, Donnellan L, Deo P, Kellow NJ, Cooper ME, Woodruff TM, Mackay CR, Forbes JM, Coughlan MT. Snelson M, et al. Among authors: mackay cr. Sci Adv. 2021 Mar 31;7(14):eabe4841. doi: 10.1126/sciadv.abe4841. Print 2021 Mar. Sci Adv. 2021. PMID: 33789895 Free PMC article.
249 results