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Unusual dimeric flavonoids (brachydins) induce ultrastructural membrane alterations associated with antitumor activity in cancer cell lines.
Maciel-Silva VL, da Rocha CQ, Alencar LMR, Castelo-Branco PV, Sousa IH, Azevedo-Santos AP, Vale AAM, Monteiro SG, Soares RP, Guimarães SJA, Nascimento JRD, Pereira SRF. Maciel-Silva VL, et al. Drug Chem Toxicol. 2023 Nov;46(4):665-676. doi: 10.1080/01480545.2022.2080217. Epub 2022 May 29. Drug Chem Toxicol. 2023. PMID: 35635136
Ruthenium (II) complexes with N, O-chelating proline and threonine ligands cause selective cytotoxicity by the induction of genomic instability, cell cycle arrest and apoptosis in breast and prostate tumor cells.
de Sousa IH, Campos VNS, Vale AAM, Maciel-Silva VL, Leite CM, Lopes AJO, Mourão PS, das Chagas Alves Lima F, Batista AA, de Azevedo Dos Santos APS, Almeida MAP, Pereira SRF. de Sousa IH, et al. Among authors: maciel silva vl. Toxicol In Vitro. 2020 Feb;62:104679. doi: 10.1016/j.tiv.2019.104679. Epub 2019 Oct 30. Toxicol In Vitro. 2020. PMID: 31676337
Ascorbic acid reduces the genetic damage caused by miltefosine (hexadecylphosphocholine) in animals infected by Leishmania (Leishamnia) infantum without decreasing its antileishmanial activity.
Castelo-Branco PV, Alves HJ, Pontes RL, Maciel-Silva VL, Ferreira Pereira SR. Castelo-Branco PV, et al. Among authors: maciel silva vl. Int J Parasitol Drugs Drug Resist. 2019 Apr;9:8-15. doi: 10.1016/j.ijpddr.2018.12.002. Epub 2018 Dec 13. Int J Parasitol Drugs Drug Resist. 2019. PMID: 30578864 Free PMC article.