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Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products.
Silva-Fernandes A, Costa Mdo C, Duarte-Silva S, Oliveira P, Botelho CM, Martins L, Mariz JA, Ferreira T, Ribeiro F, Correia-Neves M, Costa C, Maciel P. Silva-Fernandes A, et al. Among authors: maciel p. Neurobiol Dis. 2010 Oct;40(1):163-76. doi: 10.1016/j.nbd.2010.05.021. Epub 2010 May 25. Neurobiol Dis. 2010. PMID: 20510362
Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome.
Santos M, Summavielle T, Teixeira-Castro A, Silva-Fernandes A, Duarte-Silva S, Marques F, Martins L, Dierssen M, Oliveira P, Sousa N, Maciel P. Santos M, et al. Among authors: maciel p. Neuroscience. 2010 Oct 13;170(2):453-67. doi: 10.1016/j.neuroscience.2010.07.010. Epub 2010 Jul 13. Neuroscience. 2010. PMID: 20633611
Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.
Neves-Carvalho A, Logarinho E, Freitas A, Duarte-Silva S, Costa Mdo C, Silva-Fernandes A, Martins M, Serra SC, Lopes AT, Paulson HL, Heutink P, Relvas JB, Maciel P. Neves-Carvalho A, et al. Among authors: maciel p. Hum Mol Genet. 2015 Jan 1;24(1):100-17. doi: 10.1093/hmg/ddu422. Epub 2014 Aug 20. Hum Mol Genet. 2015. PMID: 25143392 Free PMC article.
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.
Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, Neto MF, Brielmann RM, Bessa C, Duarte-Silva S, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, Silverman RB, Oliveira P, Morimoto RI, Maciel P. Teixeira-Castro A, et al. Among authors: maciel p. Brain. 2015 Nov;138(Pt 11):3221-37. doi: 10.1093/brain/awv262. Epub 2015 Sep 15. Brain. 2015. PMID: 26373603 Free PMC article.
225 results