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BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice.
Cattaneo M, Aleksova A, Malovini A, Avolio E, Thomas A, Alvino VV, Kilcooley M, Pieronne-Deperrois M, Ouvrard-Pascaud A, Maciag A, Spinetti G, Kussauer S, Lemcke H, Skorska A, Vasudevan P, Castiglione S, Raucci A, David R, Richard V, Beltrami AP, Madeddu P, Puca AA. Cattaneo M, et al. Among authors: maciag a. Cell Death Dis. 2023 Aug 15;14(8):523. doi: 10.1038/s41419-023-06011-8. Cell Death Dis. 2023. PMID: 37582912 Free PMC article.
Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway.
Dang Z, Avolio E, Thomas AC, Faulkner A, Beltrami AP, Cervellin C, Carrizzo A, Maciag A, Gu Y, Ciaglia E, Finato N, Damato A, Spinetti G, Alenzi A, Paisey SJ, Vecchione C, Puca AA, Madeddu P. Dang Z, et al. Among authors: maciag a. Eur J Heart Fail. 2020 Sep;22(9):1568-1581. doi: 10.1002/ejhf.1840. Epub 2020 May 8. Eur J Heart Fail. 2020. PMID: 32384208 Free PMC article.
The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.
Di Pardo A, Ciaglia E, Cattaneo M, Maciag A, Montella F, Lopardo V, Ferrario A, Villa F, Madonna M, Amico E, Carrizzo A, Damato A, Pepe G, Marracino F, Auricchio A, Vecchione C, Maglione V, Puca AA. Di Pardo A, et al. Among authors: maciag a. Cell Death Dis. 2020 Jul 18;11(7):546. doi: 10.1038/s41419-020-02754-w. Cell Death Dis. 2020. PMID: 32683420 Free PMC article.
The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.
Cattaneo M, Beltrami AP, Thomas AC, Spinetti G, Alvino VV, Avolio E, Veneziano C, Rolle IG, Sponga S, Sangalli E, Maciag A, Dal Piaz F, Vecchione C, Alenezi A, Paisey S, Puca AA, Madeddu P. Cattaneo M, et al. Among authors: maciag a. Cardiovasc Res. 2023 Jul 4;119(7):1583-1595. doi: 10.1093/cvr/cvad008. Cardiovasc Res. 2023. PMID: 36635236 Free PMC article.
Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.
Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciąg A, Damato A, Auricchio A, Spinetti G, Sangalli E, Dang Z, Madonna M, Ambrosio M, Sitia L, Bigini P, Calì G, Schreiber S, Perls T, Fucile S, Mulas F, Nebel A, Bellazzi R, Madeddu P, Vecchione C, Puca AA. Villa F, et al. Among authors: maciag a. Circ Res. 2015 Jul 31;117(4):333-45. doi: 10.1161/CIRCRESAHA.117.305875. Epub 2015 Jun 1. Circ Res. 2015. PMID: 26034043 Free PMC article.
Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism.
Puca AA, Carrizzo A, Spinelli C, Damato A, Ambrosio M, Villa F, Ferrario A, Maciag A, Fornai F, Lenzi P, Valenti V, di Nonno F, Accarino G, Madonna M, Forte M, Calì G, Baragetti A, Norata GD, Catapano AL, Cattaneo M, Izzo R, Trimarco V, Montella F, Versaci F, Auricchio A, Frati G, Sciarretta S, Madeddu P, Ciaglia E, Vecchione C. Puca AA, et al. Among authors: maciag a. Eur Heart J. 2020 Jul 7;41(26):2487-2497. doi: 10.1093/eurheartj/ehz459. Eur Heart J. 2020. PMID: 31289820 Free PMC article.
LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.
Malavolta M, Dato S, Villa F, Rango F, Iannone F, Ferrario A, Maciag A, Ciaglia E, D'amato A, Carrizzo A, Basso A, Orlando F, Provinciali M, Madeddu P, Passarino G, Vecchione C, Rose G, Puca AA. Malavolta M, et al. Among authors: maciag a. Aging (Albany NY). 2019 Aug 28;11(16):6555-6568. doi: 10.18632/aging.102209. Epub 2019 Aug 28. Aging (Albany NY). 2019. PMID: 31461407 Free PMC article.
165 results