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Platelet bioreactor-on-a-chip.
Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE Jr. Thon JN, et al. Among authors: machlus kr. Blood. 2014 Sep 18;124(12):1857-67. doi: 10.1182/blood-2014-05-574913. Blood. 2014. PMID: 25606631 Free PMC article.
T granules in human platelets function in TLR9 organization and signaling.
Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE Jr. Thon JN, et al. Among authors: machlus kr. J Cell Biol. 2012 Aug 20;198(4):561-74. doi: 10.1083/jcb.201111136. J Cell Biol. 2012. PMID: 22908309 Free PMC article.
Proteasome function is required for platelet production.
Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS. Shi DS, et al. Among authors: machlus kr. J Clin Invest. 2014 Sep;124(9):3757-66. doi: 10.1172/JCI75247. Epub 2014 Jul 25. J Clin Invest. 2014. PMID: 25061876 Free PMC article.
Scalable generation of universal platelets from human induced pluripotent stem cells.
Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R. Feng Q, et al. Among authors: machlus kr. Stem Cell Reports. 2014 Nov 11;3(5):817-31. doi: 10.1016/j.stemcr.2014.09.010. Epub 2014 Oct 16. Stem Cell Reports. 2014. PMID: 25418726 Free PMC article.
Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice.
Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus KR, Ranelletti FO, Gianellini S, Weksler B, Italiano JE Jr, Tremoli E. Barbieri SS, et al. Among authors: machlus kr. Thromb Haemost. 2015 Nov 25;114(6):1218-29. doi: 10.1160/TH14-10-0872. Epub 2015 Aug 13. Thromb Haemost. 2015. PMID: 26272103
CCL5 derived from platelets increases megakaryocyte proplatelet formation.
Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE Jr, Battinelli EM. Machlus KR, et al. Blood. 2016 Feb 18;127(7):921-6. doi: 10.1182/blood-2015-05-644583. Epub 2015 Dec 8. Blood. 2016. PMID: 26647394 Free PMC article.
60 results