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Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells.
Amodeo V, Davies T, Martinez-Segura A, Clements MP, Ragdale HS, Bailey A, Dos Santos MS, MacRae JI, Mokochinski J, Kramer H, Garcia-Diaz C, Gould AP, Marguerat S, Parrinello S. Amodeo V, et al. Among authors: macrae ji. Dev Cell. 2023 May 22;58(10):836-846.e6. doi: 10.1016/j.devcel.2023.03.021. Epub 2023 Apr 20. Dev Cell. 2023. PMID: 37084728 Free PMC article.
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer.
Wu MY, Shepherd STC, Fendler A, Carr EJ, Au L, Harvey R, Dowgier G, Hobbs A, Herman LS, Ragno M, Adams L, Schmitt AM, Tippu Z, Shum B, Farag S, Rogiers A, O'Reilly N, Bawumia P, Smith C, Carlyle E, Edmonds K, Del Rosario L, Lingard K, Mangwende M, Holt L, Ahmod H, Korteweg J, Foley T, Barber T, Hepworth S, Emslie-Henry A, Caulfield-Lynch N, Byrne F, Deng D, Williams B, Brown M, Caidan S, Gavrielides M, MacRae JI, Kelly G, Peat K, Kelly D, Murra A, Kelly K, O'Flaherty M, Popat S, Yousaf N, Jhanji S, Tatham K, Cunningham D, Van As N, Young K, Furness AJS, Pickering L, Beale R, Swanton C, Gandhi S, Gamblin S, Bauer DLV, Kassiotis G, Howell M, Walker S, Nicholson E, Larkin J, Wall EC, Turajlic S; CAPTURE consortium. Wu MY, et al. Among authors: macrae ji. Cancer Cell. 2023 May 8;41(5):821-823. doi: 10.1016/j.ccell.2023.04.005. Epub 2023 Apr 13. Cancer Cell. 2023. PMID: 37116490 Free PMC article.
A malaria parasite phospholipase facilitates efficient asexual blood stage egress.
Ramaprasad A, Burda PC, Koussis K, Thomas JA, Pietsch E, Calvani E, Howell SA, MacRae JI, Snijders AP, Gilberger TW, Blackman MJ. Ramaprasad A, et al. Among authors: macrae ji. PLoS Pathog. 2023 Jun 23;19(6):e1011449. doi: 10.1371/journal.ppat.1011449. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37352369 Free PMC article.
Vitamin D regulates microbiome-dependent cancer immunity.
Giampazolias E, Pereira da Costa M, Lam KC, Lim KHJ, Cardoso A, Piot C, Chakravarty P, Blasche S, Patel S, Biram A, Castro-Dopico T, Buck MD, Rodrigues RR, Poulsen GJ, Palma-Duran SA, Rogers NC, Koufaki MA, Minutti CM, Wang P, Vdovin A, Frederico B, Childs E, Lee S, Simpson B, Iseppon A, Omenetti S, Kelly G, Goldstone R, Nye E, Suárez-Bonnet A, Priestnall SL, MacRae JI, Zelenay S, Patil KR, Litchfield K, Lee JC, Jess T, Goldszmid RS, Reis E Sousa C. Giampazolias E, et al. Among authors: macrae ji. Science. 2024 Apr 26;384(6694):428-437. doi: 10.1126/science.adh7954. Epub 2024 Apr 25. Science. 2024. PMID: 38662827 Free PMC article.
PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma.
D'Avola A, Legrave N, Tajan M, Chakravarty P, Shearer RL, King HW, Kluckova K, Cheung EC, Clear AJ, Gunawan AS, Zhang L, James LK, MacRae JI, Gribben JG, Calado DP, Vousden KH, Riches JC. D'Avola A, et al. Among authors: macrae ji. J Clin Invest. 2024 Feb 15;134(4):e179917. doi: 10.1172/JCI179917. J Clin Invest. 2024. PMID: 38357928 Free PMC article. No abstract available.
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation.
Ocasio CA, Baggelaar MP, Sipthorp J, Losada de la Lastra A, Tavares M, Volarić J, Soudy C, Storck EM, Houghton JW, Palma-Duran SA, MacRae JI, Tomić G, Carr L, Downward J, Eggert US, Tate EW. Ocasio CA, et al. Among authors: macrae ji. Nat Biotechnol. 2024 Jan 8. doi: 10.1038/s41587-023-02030-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38191663
T cell migration requires ion and water influx to regulate actin polymerization.
de Boer LL, Vanes L, Melgrati S, Biggs O'May J, Hayward D, Driscoll PC, Day J, Griffiths A, Magueta R, Morrell A, MacRae JI, Köchl R, Tybulewicz VLJ. de Boer LL, et al. Among authors: macrae ji. Nat Commun. 2023 Dec 6;14(1):7844. doi: 10.1038/s41467-023-43423-8. Nat Commun. 2023. PMID: 38057317 Free PMC article.
83 results