MacLachlan I - Search Results

1

Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.

Ma H, Dallas A, Ilves H, Shorenstein J, MacLachlan I, Klumpp K, Johnston BH. Ma H, et al. Among authors: maclachlan i. Gastroenterology. 2014 Jan;146(1):63-6.e5. doi: 10.1053/j.gastro.2013.09.049. Epub 2013 Sep 27. Gastroenterology. 2014. PMID: 24076507 Free PMC article.

2

Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice.

Dallas A, Ilves H, Shorenstein J, Judge A, Spitler R, Contag C, Wong SP, Harbottle RP, Maclachlan I, Johnston BH. Dallas A, et al. Among authors: maclachlan i. Mol Ther Nucleic Acids. 2013 Sep 17;2(9):e123. doi: 10.1038/mtna.2013.50. Mol Ther Nucleic Acids. 2013. PMID: 24045712 Free PMC article.

3

Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.

Dallas A, Ilves H, Ma H, Chin DJ, Maclachlan I, Klumpp K, Johnston BH. Dallas A, et al. Among authors: maclachlan i. J Virol. 2014 May;88(9):4647-56. doi: 10.1128/JVI.00105-14. Epub 2014 Jan 29. J Virol. 2014. PMID: 24478422 Free PMC article.

4

Protection against lethal Marburg virus infection mediated by lipid encapsulated small interfering RNA.

Ursic-Bedoya R, Mire CE, Robbins M, Geisbert JB, Judge A, MacLachlan I, Geisbert TW. Ursic-Bedoya R, et al. Among authors: maclachlan i. J Infect Dis. 2014 Feb 15;209(4):562-70. doi: 10.1093/infdis/jit465. Epub 2013 Aug 29. J Infect Dis. 2014. PMID: 23990568 Free PMC article.

5

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates.

Thi EP, Mire CE, Lee AC, Geisbert JB, Zhou JZ, Agans KN, Snead NM, Deer DJ, Barnard TR, Fenton KA, MacLachlan I, Geisbert TW. Thi EP, et al. Among authors: maclachlan i. Nature. 2015 May 21;521(7552):362-5. doi: 10.1038/nature14442. Epub 2015 Apr 22. Nature. 2015. PMID: 25901685 Free PMC article.

6

Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA.

Thi EP, Mire CE, Ursic-Bedoya R, Geisbert JB, Lee ACH, Agans KN, Robbins M, Deer DJ, Fenton KA, MacLachlan I, Geisbert TW. Thi EP, et al. Among authors: maclachlan i. Sci Transl Med. 2014 Aug 20;6(250):250ra116. doi: 10.1126/scitranslmed.3009706. Sci Transl Med. 2014. PMID: 25143366 Free PMC article.

7

Overcoming the innate immune response to small interfering RNA.

Judge A, MacLachlan I. Judge A, et al. Among authors: maclachlan i. Hum Gene Ther. 2008 Feb;19(2):111-24. doi: 10.1089/hum.2007.179. Hum Gene Ther. 2008. PMID: 18230025 Review.

8

siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease.

Thi EP, Mire CE, Lee AC, Geisbert JB, Ursic-Bedoya R, Agans KN, Robbins M, Deer DJ, Cross RW, Kondratowicz AS, Fenton KA, MacLachlan I, Geisbert TW. Thi EP, et al. Among authors: maclachlan i. J Clin Invest. 2017 Dec 1;127(12):4437-4448. doi: 10.1172/JCI96185. Epub 2017 Nov 6. J Clin Invest. 2017. PMID: 29106386 Free PMC article.

9

2'-O-methyl-modified RNAs act as TLR7 antagonists.

Robbins M, Judge A, Liang L, McClintock K, Yaworski E, MacLachlan I. Robbins M, et al. Among authors: maclachlan i. Mol Ther. 2007 Sep;15(9):1663-9. doi: 10.1038/sj.mt.6300240. Epub 2007 Jun 19. Mol Ther. 2007. PMID: 17579574 Free article.

10

Rescue of non-human primates from advanced Sudan ebolavirus infection with lipid encapsulated siRNA.

Thi EP, Lee AC, Geisbert JB, Ursic-Bedoya R, Agans KN, Robbins M, Deer DJ, Fenton KA, Kondratowicz AS, MacLachlan I, Geisbert TW, Mire CE. Thi EP, et al. Among authors: maclachlan i. Nat Microbiol. 2016 Aug 22;1(10):16142. doi: 10.1038/nmicrobiol.2016.142. Nat Microbiol. 2016. PMID: 27670117 Free PMC article.

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