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Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes.
Pereboom TC, Bondt A, Pallaki P, Klasson TD, Goos YJ, Essers PB, Groot Koerkamp MJ, Gazda HT, Holstege FC, Costa LD, MacInnes AW. Pereboom TC, et al. Among authors: macinnes aw. Exp Hematol. 2014 May;42(5):394-403.e4. doi: 10.1016/j.exphem.2013.12.010. Epub 2014 Jan 23. Exp Hematol. 2014. PMID: 24463277 Free article. Clinical Trial.
Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.
Heijnen HF, van Wijk R, Pereboom TC, Goos YJ, Seinen CW, van Oirschot BA, van Dooren R, Gastou M, Giles RH, van Solinge W, Kuijpers TW, Gazda HT, Bierings MB, Da Costa L, MacInnes AW. Heijnen HF, et al. Among authors: macinnes aw. PLoS Genet. 2014 May 29;10(5):e1004371. doi: 10.1371/journal.pgen.1004371. eCollection 2014. PLoS Genet. 2014. PMID: 24875531 Free PMC article.
Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism.
Stout GJ, Stigter EC, Essers PB, Mulder KW, Kolkman A, Snijders DS, van den Broek NJ, Betist MC, Korswagen HC, Macinnes AW, Brenkman AB. Stout GJ, et al. Among authors: macinnes aw. Mol Syst Biol. 2013 Jul 2;9:679. doi: 10.1038/msb.2013.35. Mol Syst Biol. 2013. PMID: 23820781 Free PMC article.
A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension.
Essers PB, Nonnekens J, Goos YJ, Betist MC, Viester MD, Mossink B, Lansu N, Korswagen HC, Jelier R, Brenkman AB, MacInnes AW. Essers PB, et al. Among authors: macinnes aw. Cell Rep. 2015 Jan 20;10(3):339-345. doi: 10.1016/j.celrep.2014.12.029. Epub 2015 Jan 15. Cell Rep. 2015. PMID: 25600869 Free article.
30 results