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CK2 activity is crucial for proper glucagon expression.
Ampofo E, Pack M, Wrublewsky S, Boewe AS, Spigelman AF, Koch H, MacDonald PE, Laschke MW, Montenarh M, Götz C. Ampofo E, et al. Among authors: macdonald pe. Diabetologia. 2024 Mar 20. doi: 10.1007/s00125-024-06128-1. Online ahead of print. Diabetologia. 2024. PMID: 38503901
The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.
Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE. Dai XQ, et al. Among authors: macdonald pe. Diabetologia. 2012 Jun;55(6):1709-20. doi: 10.1007/s00125-012-2512-6. Epub 2012 Mar 13. Diabetologia. 2012. PMID: 22411134
Improvement of islet transplantation by the fusion of islet cells with functional blood vessels.
Nalbach L, Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Manning Fox JE, MacDonald PE, Menger MD, Laschke MW, Ampofo E. Nalbach L, et al. Among authors: macdonald pe. EMBO Mol Med. 2021 Jan 11;13(1):e12616. doi: 10.15252/emmm.202012616. Epub 2020 Nov 2. EMBO Mol Med. 2021. PMID: 33135383 Free PMC article.
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL. Mattis KK, et al. Among authors: macdonald pe. Diabetologia. 2023 Apr;66(4):674-694. doi: 10.1007/s00125-022-05856-6. Epub 2023 Jan 12. Diabetologia. 2023. PMID: 36633628 Free PMC article.
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
Lin H, Suzuki K, Smith N, Li X, Nalbach L, Fuentes S, Spigelman AF, Dai XQ, Bautista A, Ferdaoussi M, Aggarwal S, Pepper AR, Roma LP, Ampofo E, Li WH, MacDonald PE. Lin H, et al. Among authors: macdonald pe. Nat Commun. 2024 Jan 6;15(1):334. doi: 10.1038/s41467-023-44589-x. Nat Commun. 2024. PMID: 38184650 Free PMC article.
Functional plasticity of the human infant β-cell exocytotic phenotype.
Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AM, Korbutt G, MacDonald PE. Fox JE, et al. Among authors: macdonald pe. Endocrinology. 2013 Apr;154(4):1392-9. doi: 10.1210/en.2012-1934. Epub 2013 Feb 28. Endocrinology. 2013. PMID: 23449893
143 results