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Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.
Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA. Platnich JM, et al. Among authors: macdonald ja. Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071. Cell Rep. 2018. PMID: 30404007 Free article.
Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ. Beck PL, et al. Among authors: macdonald ja. Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G43-53. doi: 10.1152/ajpgi.00228.2009. Epub 2010 Mar 18. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20299601 Free PMC article.
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.
Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hirota SA, et al. Among authors: macdonald ja. Gastroenterology. 2010 Jul;139(1):259-69.e3. doi: 10.1053/j.gastro.2010.03.045. Epub 2010 Mar 27. Gastroenterology. 2010. PMID: 20347817 Free PMC article.
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.
Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL. Hirota SA, et al. Among authors: macdonald ja. Inflamm Bowel Dis. 2011 Jun;17(6):1359-72. doi: 10.1002/ibd.21478. Epub 2010 Sep 24. Inflamm Bowel Dis. 2011. PMID: 20872834 Free PMC article.
344 results