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A potential new tool for managing Clostridium difficile infection.
Armstrong GD, Pillai DR, Louie TJ, MacDonald JA, Beck PL. Armstrong GD, et al. Among authors: macdonald ja. J Infect Dis. 2013 May 15;207(10):1484-6. doi: 10.1093/infdis/jit069. Epub 2013 Feb 18. J Infect Dis. 2013. PMID: 23420904 No abstract available.
Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.
Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, MacDonald JA, Beck PL. Hirota SA, et al. Among authors: macdonald ja. Gastroenterology. 2010 Jul;139(1):259-69.e3. doi: 10.1053/j.gastro.2010.03.045. Epub 2010 Mar 27. Gastroenterology. 2010. PMID: 20347817 Free PMC article.
Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure.
Hirota SA, Iablokov V, Tulk SE, Schenck LP, Becker H, Nguyen J, Al Bashir S, Dingle TC, Laing A, Liu J, Li Y, Bolstad J, Mulvey GL, Armstrong GD, MacNaughton WK, Muruve DA, MacDonald JA, Beck PL. Hirota SA, et al. Among authors: macdonald ja. Infect Immun. 2012 Dec;80(12):4474-84. doi: 10.1128/IAI.00933-12. Epub 2012 Oct 8. Infect Immun. 2012. PMID: 23045481 Free PMC article.
The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.
Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA. Hansen A, et al. Among authors: macdonald ja. PLoS One. 2013 Nov 22;8(11):e81491. doi: 10.1371/journal.pone.0081491. eCollection 2013. PLoS One. 2013. PMID: 24278446 Free PMC article.
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.
Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA. Platnich JM, et al. Among authors: macdonald ja. Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071. Cell Rep. 2018. PMID: 30404007 Free article.
Attenuation of Clostridium difficile toxin-induced damage to epithelial barrier by ecto-5'-nucleotidase (CD73) and adenosine receptor signaling.
Schenck LP, Hirota SA, Hirota CL, Boasquevisque P, Tulk SE, Li Y, Wadhwani A, Doktorchik CT, Macnaughton WK, Beck PL, MacDonald JA. Schenck LP, et al. Among authors: macdonald ja. Neurogastroenterol Motil. 2013 Jun;25(6):e441-53. doi: 10.1111/nmo.12139. Epub 2013 Apr 21. Neurogastroenterol Motil. 2013. PMID: 23600886
344 results