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Mitochondrial DNA competition: starving out the mutant genome.
Spinazzola A, Perez-Rodriguez D, Ježek J, Holt IJ. Spinazzola A, et al. Trends Pharmacol Sci. 2024 Mar;45(3):225-242. doi: 10.1016/j.tips.2024.01.011. Epub 2024 Feb 23. Trends Pharmacol Sci. 2024. PMID: 38402076 Free article. Review.
Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation.
Muñoz-Oreja M, Sandoval A, Bruland O, Perez-Rodriguez D, Fernandez-Pelayo U, de Arbina AL, Villar-Fernandez M, Hernández-Eguiazu H, Hernández I, Park Y, Goicoechea L, Pascual-Frías N, Garcia-Ruiz C, Fernandez-Checa J, Martí-Carrera I, Gil-Bea FJ, Hasan MT, Gegg ME, Bredrup C, Knappskog PM, Gereñu-Lopetegui G, Varhaug KN, Bindoff LA, Spinazzola A, Yoon WH, Holt IJ. Muñoz-Oreja M, et al. Brain. 2024 May 3;147(5):1899-1913. doi: 10.1093/brain/awae018. Brain. 2024. PMID: 38242545 Free PMC article.