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The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
Pras A, Houben B, Aprile FA, Seinstra R, Gallardo R, Janssen L, Hogewerf W, Gallrein C, De Vleeschouwer M, Mata-Cabana A, Koopman M, Stroo E, de Vries M, Louise Edwards S, Kirstein J, Vendruscolo M, Falsone SF, Rousseau F, Schymkowitz J, Nollen EAA. Pras A, et al. EMBO J. 2021 Nov 2;40(21):e107568. doi: 10.15252/embj.2020107568. Epub 2021 Oct 7. EMBO J. 2021. PMID: 34617299 Free PMC article.
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.
Scheidt T, Carozza JA, Kolbe CC, Aprile FA, Tkachenko O, Bellaiche MMJ, Meisl G, Peter QAE, Herling TW, Ness S, Castellana-Cruz M, Benesch JLP, Vendruscolo M, Dobson CM, Arosio P, Knowles TPJ. Scheidt T, et al. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2108790118. doi: 10.1073/pnas.2108790118. Proc Natl Acad Sci U S A. 2021. PMID: 34518228 Free PMC article.
19 results