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CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury.
McKendrick JG, Jones GR, Elder SS, Watson E, T'Jonck W, Mercer E, Magalhaes MS, Rocchi C, Hegarty LM, Johnson AL, Schneider C, Becher B, Pridans C, Mabbott N, Liu Z, Ginhoux F, Bajenoff M, Gentek R, Bain CC, Emmerson E. McKendrick JG, et al. Sci Immunol. 2023 Nov 3;8(89):eadd4374. doi: 10.1126/sciimmunol.add4374. Epub 2023 Nov 3. Sci Immunol. 2023. PMID: 37922341
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Rojo R, et al. Nat Commun. 2019 Jul 19;10(1):3215. doi: 10.1038/s41467-019-11053-8. Nat Commun. 2019. PMID: 31324781 Free PMC article.