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Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa.
Soukarieh F, Mashabi A, Richardson W, Oton EV, Romero M, Roberston SN, Grossman S, Sou T, Liu R, Halliday N, Kukavica-Ibrulj I, Levesque RC, Bergstrom CAS, Kellam B, Emsley J, Heeb S, Williams P, Stocks MJ, Cámara M. Soukarieh F, et al. ACS Infect Dis. 2021 Sep 10;7(9):2666-2685. doi: 10.1021/acsinfecdis.1c00175. Epub 2021 Aug 17. ACS Infect Dis. 2021. PMID: 34503335 Free article.
Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1 sub-unit.
Soh EY, Smith F, Gimenez MR, Yang L, Vejborg RM, Fletcher M, Halliday N, Bleves S, Heeb S, Cámara M, Givskov M, Hardie KR, Tolker-Nielsen T, Ize B, Williams P. Soh EY, et al. PLoS Pathog. 2021 Aug 30;17(8):e1009425. doi: 10.1371/journal.ppat.1009425. eCollection 2021 Aug. PLoS Pathog. 2021. PMID: 34460871 Free PMC article.