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Page 1
11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial.
Othonos N, Pofi R, Arvaniti A, White S, Bonaventura I, Nikolaou N, Moolla A, Marjot T, Stimson RH, van Beek AP, van Faassen M, Isidori AM, Bateman E, Sadler R, Karpe F, Stewart PM, Webster C, Duffy J, Eastell R, Gossiel F, Cornfield T, Hodson L, Jane Escott K, Whittaker A, Kirik U, Coleman RL, Scott CAB, Milton JE, Agbaje O, Holman RR, Tomlinson JW. Othonos N, et al. Nat Commun. 2023 Feb 23;14(1):1025. doi: 10.1038/s41467-023-36541-w. Nat Commun. 2023. PMID: 36823106 Free PMC article. Clinical Trial.
Is autonomous cortisol secretion sexually dimorphic?
Pofi R, Tomlinson JW. Pofi R, et al. Lancet Diabetes Endocrinol. 2022 Jul;10(7):473-475. doi: 10.1016/S2213-8587(22)00110-3. Epub 2022 May 6. Lancet Diabetes Endocrinol. 2022. PMID: 35533705 No abstract available.
Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents.
Hazlehurst JM, Lim TR, Charlton C, Miller JJ, Gathercole LL, Cornfield T, Nikolaou N, Harris SE, Moolla A, Othonos N, Heather LC, Marjot T, Tyler DJ, Carr C, Hodson L, McKeating J, Tomlinson JW. Hazlehurst JM, et al. Metabol Open. 2022 Mar 14;14:100177. doi: 10.1016/j.metop.2022.100177. eCollection 2022 Jun. Metabol Open. 2022. PMID: 35313531 Free PMC article.
Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension.
Westgate CS, Botfield HF, Alimajstorovic Z, Yiangou A, Walsh M, Smith G, Singhal R, Mitchell JL, Grech O, Markey KA, Hebenstreit D, Tennant DA, Tomlinson JW, Mollan SP, Ludwig C, Akerman I, Lavery GG, Sinclair AJ. Westgate CS, et al. JCI Insight. 2021 May 24;6(10):e145346. doi: 10.1172/jci.insight.145346. JCI Insight. 2021. PMID: 33848268 Free PMC article.
11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.
Hardy RS, Botfield H, Markey K, Mitchell JL, Alimajstorovic Z, Westgate CSJ, Sagmeister M, Fairclough RJ, Ottridge RS, Yiangou A, Storbeck KH, Taylor AE, Gilligan LC, Arlt W, Stewart PM, Tomlinson JW, Mollan SP, Lavery GG, Sinclair AJ. Hardy RS, et al. J Clin Endocrinol Metab. 2021 Jan 1;106(1):174-187. doi: 10.1210/clinem/dgaa766. J Clin Endocrinol Metab. 2021. PMID: 33098644 Free PMC article. Clinical Trial.
11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial.
Markey K, Mitchell J, Botfield H, Ottridge RS, Matthews T, Krishnan A, Woolley R, Westgate C, Yiangou A, Alimajstorovic Z, Shah P, Rick C, Ives N, Taylor AE, Gilligan LC, Jenkinson C, Arlt W, Scotton W, Fairclough RJ, Singhal R, Stewart PM, Tomlinson JW, Lavery GG, Mollan SP, Sinclair AJ. Markey K, et al. Brain Commun. 2020 Jan 10;2(1):fcz050. doi: 10.1093/braincomms/fcz050. eCollection 2020. Brain Commun. 2020. PMID: 32954315 Free PMC article.
16 results