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The histone chaperone SPT2 regulates chromatin structure and function in Metazoa.
Saredi G, Carelli FN, Rolland SGM, Furlan G, Piquet S, Appert A, Sanchez-Pulido L, Price JL, Alcon P, Lampersberger L, Déclais AC, Ramakrishna NB, Toth R, Macartney T, Alabert C, Ponting CP, Polo SE, Miska EA, Gartner A, Ahringer J, Rouse J. Saredi G, et al. Nat Struct Mol Biol. 2024 Mar;31(3):523-535. doi: 10.1038/s41594-023-01204-3. Epub 2024 Jan 18. Nat Struct Mol Biol. 2024. PMID: 38238586 Free PMC article.
CDKL5 kinase controls transcription-coupled responses to DNA damage.
Khanam T, Muñoz I, Weiland F, Carroll T, Morgan M, Borsos BN, Pantazi V, Slean M, Novak M, Toth R, Appleton P, Pankotai T, Zhou H, Rouse J. Khanam T, et al. EMBO J. 2021 Dec 1;40(23):e108271. doi: 10.15252/embj.2021108271. Epub 2021 Oct 4. EMBO J. 2021. PMID: 34605059 Free PMC article.
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Álvarez-Quilón A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Muñoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Álvarez-Quilón A, et al. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. Mol Cell. 2020. PMID: 32516598 Free PMC article.