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Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB-driven inflammation and cardiovascular risk.
Zannas AS, Jia M, Hafner K, Baumert J, Wiechmann T, Pape JC, Arloth J, Ködel M, Martinelli S, Roitman M, Röh S, Haehle A, Emeny RT, Iurato S, Carrillo-Roa T, Lahti J, Räikkönen K, Eriksson JG, Drake AJ, Waldenberger M, Wahl S, Kunze S, Lucae S, Bradley B, Gieger C, Hausch F, Smith AK, Ressler KJ, Müller-Myhsok B, Ladwig KH, Rein T, Gassen NC, Binder EB. Zannas AS, et al. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11370-11379. doi: 10.1073/pnas.1816847116. Epub 2019 May 21. Proc Natl Acad Sci U S A. 2019. PMID: 31113877 Free PMC article.
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment.
Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, Kern N, Brunner J, Modell S, Baghai T, Deiml T, Zill P, Bondy B, Rupprecht R, Messer T, Köhnlein O, Dabitz H, Brückl T, Müller N, Pfister H, Lieb R, Mueller JC, Lõhmussaar E, Strom TM, Bettecken T, Meitinger T, Uhr M, Rein T, Holsboer F, Muller-Myhsok B. Binder EB, et al. Nat Genet. 2004 Dec;36(12):1319-25. doi: 10.1038/ng1479. Epub 2004 Nov 21. Nat Genet. 2004. PMID: 15565110
Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism.
Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Illig T, Wichmann HE, Modell S, Nothdurfter C, Holsboer F, Müller-Myhsok B, Möller HJ, Rupprecht R, Bondy B. Baghai TC, et al. Mol Psychiatry. 2006 Nov;11(11):1003-15. doi: 10.1038/sj.mp.4001884. Epub 2006 Aug 22. Mol Psychiatry. 2006. PMID: 16924268
Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.
Erhardt A, Lucae S, Unschuld PG, Ising M, Kern N, Salyakina D, Lieb R, Uhr M, Binder EB, Keck ME, Müller-Myhsok B, Holsboer F. Erhardt A, et al. J Affect Disord. 2007 Aug;101(1-3):159-68. doi: 10.1016/j.jad.2006.11.016. Epub 2007 Jan 2. J Affect Disord. 2007. PMID: 17197037
Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder.
Keck ME, Kern N, Erhardt A, Unschuld PG, Ising M, Salyakina D, Müller MB, Knorr CC, Lieb R, Hohoff C, Krakowitzky P, Maier W, Bandelow B, Fritze J, Deckert J, Holsboer F, Müller-Myhsok B, Binder EB. Keck ME, et al. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1196-204. doi: 10.1002/ajmg.b.30750. Am J Med Genet B Neuropsychiatr Genet. 2008. PMID: 18384079
Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients.
Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M. Heck A, et al. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):104-14. doi: 10.1002/ajmg.b.30784. Am J Med Genet B Neuropsychiatr Genet. 2009. PMID: 18484085
426 results