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The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Wiedmann RM, von Schwarzenberg K, Palamidessi A, Schreiner L, Kubisch R, Liebl J, Schempp C, Trauner D, Vereb G, Zahler S, Wagner E, Müller R, Scita G, Vollmar AM. Wiedmann RM, et al. Among authors: muller r. Cancer Res. 2012 Nov 15;72(22):5976-87. doi: 10.1158/0008-5472.CAN-12-1772. Epub 2012 Sep 17. Cancer Res. 2012. PMID: 22986742
V-ATPase inhibition overcomes trastuzumab resistance in breast cancer.
von Schwarzenberg K, Lajtos T, Simon L, Müller R, Vereb G, Vollmar AM. von Schwarzenberg K, et al. Among authors: muller r. Mol Oncol. 2014 Feb;8(1):9-19. doi: 10.1016/j.molonc.2013.08.011. Epub 2013 Sep 5. Mol Oncol. 2014. PMID: 24055142 Free PMC article.
Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
Scherer O, Steinmetz H, Kaether C, Weinigel C, Barz D, Kleinert H, Menche D, Müller R, Pergola C, Werz O. Scherer O, et al. Among authors: muller r. Biochem Pharmacol. 2014 Oct 15;91(4):490-500. doi: 10.1016/j.bcp.2014.07.028. Epub 2014 Aug 12. Biochem Pharmacol. 2014. PMID: 25107704 Free article.
Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.
Zhang S, Schneider LS, Vick B, Grunert M, Jeremias I, Menche D, Müller R, Vollmar AM, Liebl J. Zhang S, et al. Among authors: muller r. Oncotarget. 2015 Dec 22;6(41):43508-28. doi: 10.18632/oncotarget.6180. Oncotarget. 2015. PMID: 26496038 Free PMC article.
5,383 results