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Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.
Tomasovic A, Brand T, Schanbacher C, Kramer S, Hümmert MW, Godoy P, Schmidt-Heck W, Nordbeck P, Ludwig J, Homann S, Wiegering A, Shaykhutdinov T, Kratz C, Knüchel R, Müller-Hermelink HK, Rosenwald A, Frey N, Eichler J, Dobrev D, El-Armouche A, Hengstler JG, Müller OJ, Hinrichs K, Cuello F, Zernecke A, Lorenz K. Tomasovic A, et al. Among authors: muller hermelink hk, muller oj. Nat Commun. 2020 Apr 7;11(1):1733. doi: 10.1038/s41467-020-15505-4. Nat Commun. 2020. PMID: 32265441 Free PMC article.
Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.
Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K. Schmid E, et al. Among authors: muller oj. Nat Med. 2015 Nov;21(11):1298-306. doi: 10.1038/nm.3972. Epub 2015 Oct 19. Nat Med. 2015. PMID: 26479924
Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy.
Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K. Schmid E, et al. Among authors: muller oj. Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217c. Nat Med. 2016. PMID: 26845407 No abstract available.
A Novel Lipid Biomarker Panel for the Detection of Heart Failure with Reduced Ejection Fraction.
Mueller-Hennessen M, Düngen HD, Lutz M, Trippel TD, Kreuter M, Sigl J, Müller OJ, Tahirovic E, Witt H, Ternes P, Carvalho S, Peter E, Rein D, Schatz P, Herth F, Giannitsis E, Weis T, Frey N, Katus HA. Mueller-Hennessen M, et al. Among authors: muller oj. Clin Chem. 2017 Jan;63(1):267-277. doi: 10.1373/clinchem.2016.257279. Epub 2016 Oct 25. Clin Chem. 2017. PMID: 28062623
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. Lehmann LH, et al. Among authors: muller oj. Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11. Nat Med. 2018. PMID: 29227474
204 results