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Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2.
Lolicato F, Saleppico R, Griffo A, Meyer A, Scollo F, Pokrandt B, Müller HM, Ewers H, Hähl H, Fleury JB, Seemann R, Hof M, Brügger B, Jacobs K, Vattulainen I, Nickel W. Lolicato F, et al. Among authors: muller hm. J Cell Biol. 2022 Nov 7;221(11):e202106123. doi: 10.1083/jcb.202106123. Epub 2022 Sep 29. J Cell Biol. 2022. PMID: 36173379 Free PMC article.
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.
Steringer JP, Bleicken S, Andreas H, Zacherl S, Laussmann M, Temmerman K, Contreras FX, Bharat TA, Lechner J, Müller HM, Briggs JA, García-Sáez AJ, Nickel W. Steringer JP, et al. Among authors: muller hm. J Biol Chem. 2012 Aug 10;287(33):27659-69. doi: 10.1074/jbc.M112.381939. Epub 2012 Jun 23. J Biol Chem. 2012. PMID: 22730382 Free PMC article.
Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces.
Müller HM, Steringer JP, Wegehingel S, Bleicken S, Münster M, Dimou E, Unger S, Weidmann G, Andreas H, García-Sáez AJ, Wild K, Sinning I, Nickel W. Müller HM, et al. J Biol Chem. 2015 Apr 3;290(14):8925-37. doi: 10.1074/jbc.M114.622456. Epub 2015 Feb 18. J Biol Chem. 2015. PMID: 25694424 Free PMC article.
257 results