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Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
Lategahn J, Keul M, Klövekorn P, Tumbrink HL, Niggenaber J, Müller MP, Hodson L, Flaßhoff M, Hardick J, Grabe T, Engel J, Schultz-Fademrecht C, Baumann M, Ketzer J, Mühlenberg T, Hiller W, Günther G, Unger A, Müller H, Heimsoeth A, Golz C, Blank-Landeshammer B, Kollipara L, Zahedi RP, Strohmann C, Hengstler JG, van Otterlo WAL, Bauer S, Rauh D. Lategahn J, et al. Among authors: muller mp, muller h. Chem Sci. 2019 Oct 4;10(46):10789-10801. doi: 10.1039/c9sc03445e. eCollection 2019 Dec 14. Chem Sci. 2019. PMID: 31857889 Free PMC article.
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
Engel J, Smith S, Lategahn J, Tumbrink HL, Goebel L, Becker C, Hennes E, Keul M, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Hengstler JG, Rauh D. Engel J, et al. Among authors: muller h. J Med Chem. 2017 Sep 28;60(18):7725-7744. doi: 10.1021/acs.jmedchem.7b00515. Epub 2017 Sep 18. J Med Chem. 2017. PMID: 28853575
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.
Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, Hardick J, Ladigan S, Lindemann M, Smith S, Quambusch L, Scheinpflug R, Depta L, Gontla R, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Maghnouj A, Müller MP, Pohl M, Teschendorf C, Wolters H, Viebahn R, Tannapfel A, Uhl W, Hengstler JG, Hahn SA, Siveke JT, Rauh D. Weisner J, et al. Among authors: muller mp, muller h. Cancer Res. 2019 May 1;79(9):2367-2378. doi: 10.1158/0008-5472.CAN-18-2861. Epub 2019 Mar 11. Cancer Res. 2019. PMID: 30858154
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS. Cheung SY, et al. Among authors: muller h. Oncotarget. 2018 Jul 3;9(51):29634-29643. doi: 10.18632/oncotarget.25659. eCollection 2018 Jul 3. Oncotarget. 2018. PMID: 30038709 Free PMC article.
Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models.
Fischer W, Franke H, Krügel U, Müller H, Dinkel K, Lord B, Letavic MA, Henshall DC, Engel T. Fischer W, et al. Among authors: muller h. PLoS One. 2016 Jun 9;11(6):e0156468. doi: 10.1371/journal.pone.0156468. eCollection 2016. PLoS One. 2016. PMID: 27281030 Free PMC article.
Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.
Kaufmann JE, Harshfield EL, Gensicke H, Wegener S, Michel P, Kägi G, Nedeltchev K, Kellert L, Rosenbaum S, Nolte CH, Christensen H, Arnold M, Lyrer P, Levi C, Bath PM, Engelter ST, Traenka C, Markus HS; CADISS and TREAT-CAD Investigators. Kaufmann JE, et al. JAMA Neurol. 2024 May 13:e241141. doi: 10.1001/jamaneurol.2024.1141. Online ahead of print. JAMA Neurol. 2024. PMID: 38739383
A systematic comparison of deep learning methods for Gleason grading and scoring.
Dominguez-Morales JP, Duran-Lopez L, Marini N, Vicente-Diaz S, Linares-Barranco A, Atzori M, Müller H. Dominguez-Morales JP, et al. Among authors: muller h. Med Image Anal. 2024 May 4;95:103191. doi: 10.1016/j.media.2024.103191. Online ahead of print. Med Image Anal. 2024. PMID: 38728903 Free article.
Getting your DUCs in a row - standardising the representation of Digital Use Conditions.
Jeanson F, Gibson SJ, Alper P, Bernier A, Woolley JP, Mietchen D, Strug A, Becker R, Kamerling P, Sanchez Gonzalez MDC, Mah N, Novakowski A, Wilkinson MD, Benhamed OM, Landi A, Krog GP, Müller H, Riaz U, Veal C, Holub P, van Enckevort E, Brookes AJ. Jeanson F, et al. Among authors: muller h. Sci Data. 2024 May 8;11(1):464. doi: 10.1038/s41597-024-03280-6. Sci Data. 2024. PMID: 38719839 Free PMC article.
Editorial: Recent advances in pediatric craniopharyngioma.
Müller HL, Zhou J, Peng J. Müller HL, et al. Front Endocrinol (Lausanne). 2024 Apr 19;15:1413744. doi: 10.3389/fendo.2024.1413744. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38706703 Free PMC article. No abstract available.
5,998 results