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Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms.
Pott C, Muszynski A, Ruhe M, Bögeholz N, Schulte JS, Milberg P, Mönnig G, Fabritz L, Goldhaber JI, Breithardt G, Schmitz W, Philipson KD, Eckardt L, Kirchhof P, Müller FU. Pott C, et al. Among authors: muller fu. Basic Res Cardiol. 2012 Mar;107(2):247. doi: 10.1007/s00395-012-0247-7. Epub 2012 Feb 11. Basic Res Cardiol. 2012. PMID: 22327339 Free PMC article.
Triggered activity in atrial myocytes is influenced by Na+/Ca2+ exchanger activity in genetically altered mice.
Bögeholz N, Pauls P, Kaese S, Schulte JS, Lemoine MD, Dechering DG, Frommeyer G, Goldhaber JI, Seidl MD, Kirchhefer U, Eckardt L, Müller FU, Pott C. Bögeholz N, et al. Among authors: muller fu. J Mol Cell Cardiol. 2016 Dec;101:106-115. doi: 10.1016/j.yjmcc.2016.11.004. Epub 2016 Nov 9. J Mol Cell Cardiol. 2016. PMID: 27838371 Free PMC article.
Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.
Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU. Kirchhof P, et al. Among authors: muller fu. Int J Cardiol. 2013 Jun 20;166(2):366-74. doi: 10.1016/j.ijcard.2011.10.057. Epub 2011 Nov 16. Int J Cardiol. 2013. PMID: 22093963 Free PMC article.
Triadin is a critical determinant of cellular Ca cycling and contractility in the heart.
Kirchhefer U, Klimas J, Baba HA, Buchwalow IB, Fabritz L, Hüls M, Matus M, Müller FU, Schmitz W, Neumann J. Kirchhefer U, et al. Among authors: muller fu. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3165-74. doi: 10.1152/ajpheart.00799.2007. Epub 2007 Sep 21. Am J Physiol Heart Circ Physiol. 2007. PMID: 17890426 Free article.
The Effects of SEA0400 on Ca2+ Transient Amplitude and Proarrhythmia Depend on the Na+/Ca2+ Exchanger Expression Level in Murine Models.
Bögeholz N, Schulte JS, Kaese S, Bauer BK, Pauls P, Dechering DG, Frommeyer G, Goldhaber JI, Kirchhefer U, Eckardt L, Pott C, Müller FU. Bögeholz N, et al. Among authors: muller fu. Front Pharmacol. 2017 Sep 21;8:649. doi: 10.3389/fphar.2017.00649. eCollection 2017. Front Pharmacol. 2017. PMID: 28983248 Free PMC article.
Distinct Occurrence of Proarrhythmic Afterdepolarizations in Atrial Versus Ventricular Cardiomyocytes: Implications for Translational Research on Atrial Arrhythmia.
Bögeholz N, Pauls P, Dechering DG, Frommeyer G, Goldhaber JI, Pott C, Eckardt L, Müller FU, Schulte JS. Bögeholz N, et al. Among authors: muller fu. Front Pharmacol. 2018 Aug 21;9:933. doi: 10.3389/fphar.2018.00933. eCollection 2018. Front Pharmacol. 2018. PMID: 30186171 Free PMC article.
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