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Analogues of the pan-selectin antagonist rivipansel (GMI-1070).
Wagner B, Smieško M, Jakob RP, Mühlethaler T, Cramer J, Maier T, Rabbani S, Schwardt O, Ernst B. Wagner B, et al. Among authors: muhlethaler t. Eur J Med Chem. 2024 Apr 30;272:116455. doi: 10.1016/j.ejmech.2024.116455. Online ahead of print. Eur J Med Chem. 2024. PMID: 38728868
Tetra- and Hexavalent Siglec-8 Ligands Modulate Immune Cell Activation.
Conti G, Bärenwaldt A, Rabbani S, Mühlethaler T, Sarcevic M, Jiang X, Schwardt O, Ricklin D, Pieters RJ, Läubli H, Ernst B. Conti G, et al. Among authors: muhlethaler t. Angew Chem Int Ed Engl. 2023 Dec 21;62(52):e202314280. doi: 10.1002/anie.202314280. Epub 2023 Nov 23. Angew Chem Int Ed Engl. 2023. PMID: 37947772
Structural insight into the stabilization of microtubules by taxanes.
Prota AE, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, Josa-Prado F, Altmann KH, Gaillard N, Kamimura S, Mühlethaler T, Gago F, Oliva MA, Steinmetz MO, Fang WS, Díaz JF. Prota AE, et al. Among authors: muhlethaler t. Elife. 2023 Mar 6;12:e84791. doi: 10.7554/eLife.84791. Elife. 2023. PMID: 36876916 Free PMC article.
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Wranik M, Weinert T, Slavov C, Masini T, Furrer A, Gaillard N, Gioia D, Ferrarotti M, James D, Glover H, Carrillo M, Kekilli D, Stipp R, Skopintsev P, Brünle S, Mühlethaler T, Beale J, Gashi D, Nass K, Ozerov D, Johnson PJM, Cirelli C, Bacellar C, Braun M, Wang M, Dworkowski F, Milne C, Cavalli A, Wachtveitl J, Steinmetz MO, Standfuss J. Wranik M, et al. Among authors: muhlethaler t. Nat Commun. 2023 Feb 17;14(1):903. doi: 10.1038/s41467-023-36481-5. Nat Commun. 2023. PMID: 36807348 Free PMC article.
Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch.
Callegari I, Schneider M, Berloffa G, Mühlethaler T, Holdermann S, Galli E, Roloff T, Boss R, Infanti L, Khanna N, Egli A, Buser A, Zimmer G, Derfuss T, Sanderson NSR. Callegari I, et al. Among authors: muhlethaler t. EMBO Rep. 2022 Jul 5;23(7):e53956. doi: 10.15252/embr.202153956. Epub 2022 May 12. EMBO Rep. 2022. PMID: 35548920 Free PMC article.
Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Mühlethaler T, Milanos L, Ortega JA, Blum TB, Gioia D, Roy B, Prota AE, Cavalli A, Steinmetz MO. Mühlethaler T, et al. Angew Chem Int Ed Engl. 2022 Jun 20;61(25):e202204052. doi: 10.1002/anie.202204052. Epub 2022 Apr 25. Angew Chem Int Ed Engl. 2022. PMID: 35404502 Free PMC article.
21 results