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Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent.
Jernigan F, Branstrom A, Baird JD, Cao L, Dali M, Furia B, Kim MJ, O'Keefe K, Kong R, Laskin OL, Colacino JM, Pykett M, Mollin A, Sheedy J, Dumble M, Moon YC, Sheridan R, Mühlethaler T, Spiegel RJ, Prota AE, Steinmetz MO, Weetall M. Jernigan F, et al. Among authors: muhlethaler t. Mol Cancer Ther. 2021 Oct;20(10):1846-1857. doi: 10.1158/1535-7163.MCT-20-0774. Epub 2021 Jul 26. Mol Cancer Ther. 2021. PMID: 34315764 Free PMC article. Clinical Trial.
Comprehensive Analysis of Binding Sites in Tubulin.
Mühlethaler T, Gioia D, Prota AE, Sharpe ME, Cavalli A, Steinmetz MO. Mühlethaler T, et al. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13331-13342. doi: 10.1002/anie.202100273. Epub 2021 May 5. Angew Chem Int Ed Engl. 2021. PMID: 33951246 Free PMC article.
Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Mühlethaler T, Milanos L, Ortega JA, Blum TB, Gioia D, Roy B, Prota AE, Cavalli A, Steinmetz MO. Mühlethaler T, et al. Angew Chem Int Ed Engl. 2022 Jun 20;61(25):e202204052. doi: 10.1002/anie.202204052. Epub 2022 Apr 25. Angew Chem Int Ed Engl. 2022. PMID: 35404502 Free PMC article.
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.
Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF. Balaguer FA, et al. Among authors: muhlethaler t. Int J Mol Sci. 2019 Mar 20;20(6):1392. doi: 10.3390/ijms20061392. Int J Mol Sci. 2019. PMID: 30897704 Free PMC article.
VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.
Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB. Patterson JC, et al. Among authors: muhlethaler t. Cell Syst. 2019 Jul 24;9(1):74-92.e8. doi: 10.1016/j.cels.2019.05.009. Epub 2019 Jul 10. Cell Syst. 2019. PMID: 31302152 Free PMC article.
Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.
Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, Barasoain I, Song C, Sun D, Dovat S, Yunes RA, Prota AE, Steinmetz MO, Díaz JF, Yunes JA. Cury NM, et al. Among authors: muhlethaler t. iScience. 2019 Nov 22;21:95-109. doi: 10.1016/j.isci.2019.10.003. Epub 2019 Oct 2. iScience. 2019. PMID: 31655259 Free PMC article.
MAP7 family proteins regulate kinesin-1 recruitment and activation.
Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes GJ, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, Kapitein LC, Akhmanova A. Hooikaas PJ, et al. Among authors: muhlethaler t. J Cell Biol. 2019 Apr 1;218(4):1298-1318. doi: 10.1083/jcb.201808065. Epub 2019 Feb 15. J Cell Biol. 2019. PMID: 30770434 Free PMC article.
22 results