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Knowing more from less: miniaturization of ligand-binding assays and electrophoresis as new paradigms for at-line monitoring and control of mammalian cell bioprocesses.
Pinto IF, Mikkonen S, Josefsson L, Mäkinen ME, Soares RR, Russom A, Emmer Å, Chotteau V. Pinto IF, et al. Among authors: makinen me. Curr Opin Biotechnol. 2021 Oct;71:55-64. doi: 10.1016/j.copbio.2021.06.018. Epub 2021 Jul 7. Curr Opin Biotechnol. 2021. PMID: 34246047 Free article. Review. No abstract available.
Scale-down of CHO cell cultivation from shake flasks based on oxygen mass transfer allows application of parallelized, non-invasive, and time-resolved monitoring of the oxygen transfer rate in 48-well microtiter plates.
Ihling N, Berg C, Paul R, Munkler LP, Mäkinen ME, Chotteau V, Büchs J. Ihling N, et al. Among authors: makinen me. Biotechnol J. 2023 Nov;18(11):e2300053. doi: 10.1002/biot.202300053. Epub 2023 Jul 21. Biotechnol J. 2023. PMID: 37424196