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An exercise-inducible metabolite that suppresses feeding and obesity.
Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung AS, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, van de Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y, Long JZ. Li VL, et al. Among authors: lyu x. Nature. 2022 Jun;606(7915):785-790. doi: 10.1038/s41586-022-04828-5. Epub 2022 Jun 15. Nature. 2022. PMID: 35705806 Free PMC article.
CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.
Tanzo JT, Li VL, Wiggenhorn AL, Moya-Garzon MD, Wei W, Lyu X, Dong W, Tahir UA, Chen ZZ, Cruz DE, Deng S, Shi X, Zheng S, Guo Y, Sims M, Abu-Remaileh M, Wilson JG, Gerszten RE, Long JZ, Benson MD. Tanzo JT, et al. Among authors: lyu x. bioRxiv [Preprint]. 2023 Mar 9:2023.03.09.531581. doi: 10.1101/2023.03.09.531581. bioRxiv. 2023. PMID: 36945562 Free PMC article. Updated. Preprint.
CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.
Tanzo JT, Li VL, Wiggenhorn AL, Moya-Garzon MD, Wei W, Lyu X, Dong W, Tahir UA, Chen ZZ, Cruz DE, Deng S, Shi X, Zheng S, Guo Y, Sims M, Abu-Remaileh M, Wilson JG, Gerszten RE, Long JZ, Benson MD. Tanzo JT, et al. Among authors: lyu x. J Biol Chem. 2023 Jun;299(6):104764. doi: 10.1016/j.jbc.2023.104764. Epub 2023 Apr 28. J Biol Chem. 2023. PMID: 37121548 Free PMC article.
Organism-wide, cell-type-specific secretome mapping of exercise training in mice.
Wei W, Riley NM, Lyu X, Shen X, Guo J, Raun SH, Zhao M, Moya-Garzon MD, Basu H, Sheng-Hwa Tung A, Li VL, Huang W, Wiggenhorn AL, Svensson KJ, Snyder MP, Bertozzi CR, Long JZ. Wei W, et al. Among authors: lyu x. Cell Metab. 2023 Jul 11;35(7):1261-1279.e11. doi: 10.1016/j.cmet.2023.04.011. Epub 2023 May 3. Cell Metab. 2023. PMID: 37141889
Lac-Phe mediates the anti-obesity effect of metformin.
Xiao S, Li VL, Lyu X, Chen X, Wei W, Abbasi F, Knowles JW, Deng S, Tiwari G, Shi X, Zheng S, Farrell L, Chen ZZ, Taylor KD, Guo X, Goodarzi MO, Wood AC, Ida Chen YD, Lange LA, Rich SS, Rotter JI, Clish CB, Tahir UA, Gerszten RE, Benson MD, Long JZ. Xiao S, et al. Among authors: lyu x. bioRxiv [Preprint]. 2023 Nov 4:2023.11.02.565321. doi: 10.1101/2023.11.02.565321. bioRxiv. 2023. PMID: 37961394 Free PMC article. Preprint.
Lac-Phe mediates the effects of metformin on food intake and body weight.
Xiao S, Li VL, Lyu X, Chen X, Wei W, Abbasi F, Knowles JW, Tung AS, Deng S, Tiwari G, Shi X, Zheng S, Farrell L, Chen ZZ, Taylor KD, Guo X, Goodarzi MO, Wood AC, Chen YI, Lange LA, Rich SS, Rotter JI, Clish CB, Tahir UA, Gerszten RE, Benson MD, Long JZ. Xiao S, et al. Among authors: lyu x. Nat Metab. 2024 Apr;6(4):659-669. doi: 10.1038/s42255-024-00999-9. Epub 2024 Mar 18. Nat Metab. 2024. PMID: 38499766
A PTER-dependent pathway of taurine metabolism linked to energy balance.
Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, Cavanagh PE, Zeng X, Rajniak J, Lu N, Xiao S, Zhao M, Moya-Garzon MD, Truong SD, Chou JC, Wat LW, Chidambaranathan-Reghupaty S, Coassolo L, Xu D, Shen F, Huang W, Ramirez CB, Jang C, Svensson KJ, Fischbach MA, Long JZ. Wei W, et al. Among authors: lyu x. bioRxiv [Preprint]. 2024 Mar 22:2024.03.21.586194. doi: 10.1101/2024.03.21.586194. bioRxiv. 2024. PMID: 38562797 Free PMC article. Preprint.
1,430 results