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Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome.
Mathur A, Kay C, Xue Y, Pandey A, Lee J, Jing W, Enosi Tuipulotu D, Lo Pilato J, Feng S, Ngo C, Zhao A, Shen C, Rug M, Miosge LA, Atmosukarto II, Price JD, Ali SA, Gardiner EE, Robertson AA, Awad MM, Lyras D, Kaakoush NO, Man SM. Mathur A, et al. Among authors: lyras d. EMBO Rep. 2023 Jun 5;24(6):e54600. doi: 10.15252/embr.202254600. Epub 2023 Apr 19. EMBO Rep. 2023. PMID: 37073791 Free PMC article.
The alpha-toxin of Clostridium septicum is essential for virulence.
Kennedy CL, Krejany EO, Young LF, O'Connor JR, Awad MM, Boyd RL, Emmins JJ, Lyras D, Rood JI. Kennedy CL, et al. Among authors: lyras d. Mol Microbiol. 2005 Sep;57(5):1357-66. doi: 10.1111/j.1365-2958.2005.04774.x. Mol Microbiol. 2005. PMID: 16102005 Free article.
The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.
Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI. Chiarezza M, et al. Among authors: lyras d. Infect Immun. 2009 Oct;77(10):4421-8. doi: 10.1128/IAI.00548-09. Epub 2009 Aug 3. Infect Immun. 2009. PMID: 19651873 Free PMC article.
TcsL is an essential virulence factor in Clostridium sordellii ATCC 9714.
Carter GP, Awad MM, Hao Y, Thelen T, Bergin IL, Howarth PM, Seemann T, Rood JI, Aronoff DM, Lyras D. Carter GP, et al. Among authors: lyras d. Infect Immun. 2011 Mar;79(3):1025-32. doi: 10.1128/IAI.00968-10. Epub 2011 Jan 3. Infect Immun. 2011. PMID: 21199912 Free PMC article.
TcdB or not TcdB: a tale of two Clostridium difficile toxins.
Carter GP, Awad MM, Kelly ML, Rood JI, Lyras D. Carter GP, et al. Among authors: lyras d. Future Microbiol. 2011 Feb;6(2):121-3. doi: 10.2217/fmb.10.169. Future Microbiol. 2011. PMID: 21366410 Free article. No abstract available.
Opioid analgesics stop the development of clostridial gas gangrene.
Chakravorty A, Awad MM, Hiscox TJ, Cheung JK, Choo JM, Lyras D, Rood JI. Chakravorty A, et al. Among authors: lyras d. J Infect Dis. 2014 Aug 1;210(3):483-92. doi: 10.1093/infdis/jiu101. Epub 2014 Feb 18. J Infect Dis. 2014. PMID: 24550443
175 results