Lynch MJ - Search Results

1

Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling.

Lynch MJ, Hill EV, Houslay MD. Lynch MJ, et al. Curr Top Dev Biol. 2006;75:225-59. doi: 10.1016/S0070-2153(06)75007-4. Curr Top Dev Biol. 2006. PMID: 16984814 Review.

2

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

Lynch MJ, Baillie GS, Houslay MD. Lynch MJ, et al. Biochem Soc Trans. 2007 Nov;35(Pt 5):938-41. doi: 10.1042/BST0350938. Biochem Soc Trans. 2007. PMID: 17956250 Review.

3

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.

Johnston LA, Erdogan S, Cheung YF, Sullivan M, Barber R, Lynch MJ, Baillie GS, Van Heeke G, Adams DR, Huston E, Houslay MD. Johnston LA, et al. Among authors: lynch mj. Biochem J. 2004 Jun 1;380(Pt 2):371-84. doi: 10.1042/BJ20031662. Biochem J. 2004. PMID: 15025561 Free PMC article.

4

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.

McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: lynch mj. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070

5

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

Lynch MJ, Baillie GS, Mohamed A, Li X, Maisonneuve C, Klussmann E, van Heeke G, Houslay MD. Lynch MJ, et al. J Biol Chem. 2005 Sep 30;280(39):33178-89. doi: 10.1074/jbc.M414316200. Epub 2005 Jul 19. J Biol Chem. 2005. PMID: 16030021 Free article.

6

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

Li X, Huston E, Lynch MJ, Houslay MD, Baillie GS. Li X, et al. Among authors: lynch mj. Biochem J. 2006 Mar 1;394(Pt 2):427-35. doi: 10.1042/BJ20051560. Biochem J. 2006. PMID: 16356165 Free PMC article.

7

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

Terrin A, Di Benedetto G, Pertegato V, Cheung YF, Baillie G, Lynch MJ, Elvassore N, Prinz A, Herberg FW, Houslay MD, Zaccolo M. Terrin A, et al. Among authors: lynch mj. J Cell Biol. 2006 Nov 6;175(3):441-51. doi: 10.1083/jcb.200605050. J Cell Biol. 2006. PMID: 17088426 Free PMC article.

8

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

McCahill A, Campbell L, McSorley T, Sood A, Lynch MJ, Li X, Yan C, Baillie GS, Houslay MD. McCahill A, et al. Among authors: lynch mj. Cell Signal. 2008 Nov;20(11):2071-83. doi: 10.1016/j.cellsig.2008.07.017. Epub 2008 Aug 5. Cell Signal. 2008. PMID: 18721873

9

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

Huston E, Lynch MJ, Mohamed A, Collins DM, Hill EV, MacLeod R, Krause E, Baillie GS, Houslay MD. Huston E, et al. Among authors: lynch mj. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12791-6. doi: 10.1073/pnas.0805167105. Epub 2008 Aug 26. Proc Natl Acad Sci U S A. 2008. PMID: 18728186 Free PMC article.

10

The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release.

Ong WK, Gribble FM, Reimann F, Lynch MJ, Houslay MD, Baillie GS, Furman BL, Pyne NJ. Ong WK, et al. Among authors: lynch mj. Br J Pharmacol. 2009 Jun;157(4):633-44. doi: 10.1111/j.1476-5381.2009.00194.x. Epub 2009 Apr 9. Br J Pharmacol. 2009. PMID: 19371330 Free PMC article.

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