Lynch KR - Search Results

1

Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects.

Busey GW, Manjegowda MC, Huang T, Iobst WH, Naphade SS, Kennedy JA, Doyle CA, Seegren PV, Lynch KR, Desai BN. Busey GW, et al. Among authors: lynch kr. J Gen Physiol. 2024 Jan 1;156(1):e202313419. doi: 10.1085/jgp.202313419. Epub 2023 Nov 9. J Gen Physiol. 2024. PMID: 37943249 Free PMC article.

2

Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.

Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Kennedy PC, et al. Among authors: lynch kr. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89. doi: 10.1124/jpet.111.181552. Epub 2011 Jun 1. J Pharmacol Exp Ther. 2011. PMID: 21632869 Free PMC article.

3

Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors.

Kharel Y, Huang T, Santos WL, Lynch KR. Kharel Y, et al. Among authors: lynch kr. SLAS Discov. 2023 Sep;28(6):284-287. doi: 10.1016/j.slasd.2023.07.001. Epub 2023 Jul 16. SLAS Discov. 2023. PMID: 37454972 Free article.

4

Mechanism of sphingosine 1-phosphate clearance from blood.

Kharel Y, Huang T, Salamon A, Harris TE, Santos WL, Lynch KR. Kharel Y, et al. Among authors: lynch kr. Biochem J. 2020 Mar 13;477(5):925-935. doi: 10.1042/BCJ20190730. Biochem J. 2020. PMID: 32065229 Free PMC article.

5

2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2).

Burgio AL, Shrader CW, Kharel Y, Huang T, Salamoun JM, Lynch KR, Santos WL. Burgio AL, et al. Among authors: lynch kr. J Med Chem. 2023 Apr 27;66(8):5873-5891. doi: 10.1021/acs.jmedchem.3c00149. Epub 2023 Apr 3. J Med Chem. 2023. PMID: 37010497 Free PMC article.

6

Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors.

Shrader CW, Foster D, Kharel Y, Huang T, Lynch KR, Santos WL. Shrader CW, et al. Among authors: lynch kr. Bioorg Med Chem Lett. 2023 Nov 15;96:129516. doi: 10.1016/j.bmcl.2023.129516. Epub 2023 Oct 11. Bioorg Med Chem Lett. 2023. PMID: 37832799

7

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.

Sibley CD, Morris EA, Kharel Y, Brown AM, Huang T, Bevan DR, Lynch KR, Santos WL. Sibley CD, et al. Among authors: lynch kr. J Med Chem. 2020 Feb 13;63(3):1178-1198. doi: 10.1021/acs.jmedchem.9b01508. Epub 2020 Jan 28. J Med Chem. 2020. PMID: 31895563 Free PMC article.

8

Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors.

Fritzemeier R, Foster D, Peralta A, Payette M, Kharel Y, Huang T, Lynch KR, Santos WL. Fritzemeier R, et al. Among authors: lynch kr. J Med Chem. 2022 Jun 9;65(11):7656-7681. doi: 10.1021/acs.jmedchem.1c02171. Epub 2022 May 24. J Med Chem. 2022. PMID: 35609189 Free PMC article.

9

Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors.

Li H, Sibley CD, Kharel Y, Huang T, Brown AM, Wonilowicz LG, Bevan DR, Lynch KR, Santos WL. Li H, et al. Among authors: lynch kr. Bioorg Med Chem. 2021 Jan 15;30:115941. doi: 10.1016/j.bmc.2020.115941. Epub 2020 Dec 13. Bioorg Med Chem. 2021. PMID: 33385956 Free PMC article.

10

Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury.

Stone ML, Sharma AK, Zhao Y, Charles EJ, Huerter ME, Johnston WF, Kron IL, Lynch KR, Laubach VE. Stone ML, et al. Among authors: lynch kr. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 15;308(12):L1245-52. doi: 10.1152/ajplung.00302.2014. Epub 2015 Apr 24. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25910934 Free PMC article.

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