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Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target.
Kharel Y, Huang T, Dunnavant K, Foster D, Souza G, Nimchuk KE, Merchak AR, Pavelec CM, Juskiewicz ZJ, Gaultier A, Abbott S, Shin JB, Isakson BE, Xu W, Leitinger N, Santos WL, Lynch KR. Kharel Y, et al. Among authors: lynch kr. bioRxiv [Preprint]. 2024 Apr 30:2024.03.26.586765. doi: 10.1101/2024.03.26.586765. bioRxiv. 2024. PMID: 38746194 Free PMC article. Preprint.
Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors.
Shrader CW, Foster D, Kharel Y, Huang T, Lynch KR, Santos WL. Shrader CW, et al. Among authors: lynch kr. Bioorg Med Chem Lett. 2023 Nov 15;96:129516. doi: 10.1016/j.bmcl.2023.129516. Epub 2023 Oct 11. Bioorg Med Chem Lett. 2023. PMID: 37832799
Novel TRPM7 inhibitors with potent anti-inflammatory effects in vivo.
Busey GW, Manjegowda MC, Huang T, Iobst WH, Naphade SS, Kennedy JA, Doyle CA, Seegren PV, Lynch KR, Desai BN. Busey GW, et al. Among authors: lynch kr. bioRxiv [Preprint]. 2023 Aug 26:2023.05.22.541802. doi: 10.1101/2023.05.22.541802. bioRxiv. 2023. PMID: 37662207 Free PMC article. Preprint.
Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney.
Tanaka S, Zheng S, Kharel Y, Fritzemeier RG, Huang T, Foster D, Poudel N, Goggins E, Yamaoka Y, Rudnicka KP, Lipsey JE, Radel HV, Ryuh SM, Inoue T, Yao J, Rosin DL, Schwab SR, Santos WL, Lynch KR, Okusa MD. Tanaka S, et al. Among authors: lynch kr. Sci Transl Med. 2022 Aug 17;14(658):eabj2681. doi: 10.1126/scitranslmed.abj2681. Epub 2022 Aug 17. Sci Transl Med. 2022. PMID: 35976996 Free PMC article.
245 results