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Kilo-Scale GMP Synthesis of Renewable Semisynthetic Vaccine-Grade Squalene.
Fisher KJ, Shirtcliff L, Buchanan G, Thompson AW, Woolard FX, LaMunyon DH, Marshall JL, Baranouskas MB, Voelker RB, Lusk JS, Wells CE, Mohamath R, Kinsey R, Lykins WR, Ramer-Denisoff G, Fox CB, Paddon CJ, McPhee D. Fisher KJ, et al. Among authors: lykins wr. Org Process Res Dev. 2023 Dec 15;27(12):2317-2328. doi: 10.1021/acs.oprd.3c00300. Epub 2023 Nov 16. Org Process Res Dev. 2023. PMID: 38524776
Screening of Oligomeric (Meth)acrylate Vaccine Adjuvants Synthesized via Catalytic Chain Transfer Polymerization.
Hege CS, Stimpson A, Sefton J, Summers J, Henke H, Dundas AA, Phan T, Kinsey R, Guderian JA, Sivananthan SJ, Mohamath R, Lykins WR, Ramer-Denisoff G, Lin S, Fox CB, Irvine DJ. Hege CS, et al. Among authors: lykins wr. Polymers (Basel). 2023 Sep 20;15(18):3831. doi: 10.3390/polym15183831. Polymers (Basel). 2023. PMID: 37765685 Free PMC article.
Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions.
Fisher KJ, Kinsey R, Mohamath R, Phan T, Liang H, Orr MT, Lykins WR, Guderian JA, Bakken J, Argilla D, Ramer-Denisoff G, Larson E, Qi Y, Sivananthan S, Smolyar K, Carter D, Paddon CJ, Fox CB. Fisher KJ, et al. Among authors: lykins wr. NPJ Vaccines. 2023 Feb 16;8(1):14. doi: 10.1038/s41541-023-00608-y. NPJ Vaccines. 2023. PMID: 36797262 Free PMC article.
Formulated Phospholipids as Non-Canonical TLR4 Agonists.
Liang H, Lykins WR, Seydoux E, Guderian JA, Phan T, Fox CB, Orr MT. Liang H, et al. Among authors: lykins wr. Pharmaceutics. 2022 Nov 22;14(12):2557. doi: 10.3390/pharmaceutics14122557. Pharmaceutics. 2022. PMID: 36559051 Free PMC article.