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The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens.
Blasiak A, Truong ATL, Remus A, Hooi L, Seah SGK, Wang P, Chye H, Lim APC, Ng KT, Teo ST, Tan YJ, Allen DM, Chai LYA, Chng WJ, Lin RTP, Lye DCB, Wong JE, Tan GG, Chan CEZ, Chow EK, Ho D. Blasiak A, et al. Among authors: lye dcb. NPJ Digit Med. 2022 Jun 30;5(1):83. doi: 10.1038/s41746-022-00627-4. NPJ Digit Med. 2022. PMID: 35773329 Free PMC article.
Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2.
Anderson DE, Tan CW, Chia WN, Young BE, Linster M, Low JH, Tan YJ, Chen MI, Smith GJD, Leo YS, Lye DC, Wang LF. Anderson DE, et al. Emerg Microbes Infect. 2020 Dec;9(1):900-902. doi: 10.1080/22221751.2020.1761267. Emerg Microbes Infect. 2020. PMID: 32380903 Free PMC article.
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients.
Poh CM, Carissimo G, Wang B, Amrun SN, Lee CY, Chee RS, Fong SW, Yeo NK, Lee WH, Torres-Ruesta A, Leo YS, Chen MI, Tan SY, Chai LYA, Kalimuddin S, Kheng SSG, Thien SY, Young BE, Lye DC, Hanson BJ, Wang CI, Renia L, Ng LFP. Poh CM, et al. Nat Commun. 2020 Jun 1;11(1):2806. doi: 10.1038/s41467-020-16638-2. Nat Commun. 2020. PMID: 32483236 Free PMC article.
Serological differentiation between COVID-19 and SARS infections.
Chia WN, Tan CW, Foo R, Kang AEZ, Peng Y, Sivalingam V, Tiu C, Ong XM, Zhu F, Young BE, Chen MI, Tan YJ, Lye DC, Anderson DE, Wang LF. Chia WN, et al. Emerg Microbes Infect. 2020 Dec;9(1):1497-1505. doi: 10.1080/22221751.2020.1780951. Emerg Microbes Infect. 2020. PMID: 32529906 Free PMC article. Clinical Trial.
Human neutralising antibodies elicited by SARS-CoV-2 non-D614G variants offer cross-protection against the SARS-CoV-2 D614G variant.
Lee CY, Amrun SN, Chee RS, Goh YS, Mak TM, Octavia S, Yeo NK, Chang ZW, Tay MZ, Torres-Ruesta A, Carissimo G, Poh CM, Fong SW, Bei W, Lee S, Young BE, Tan SY, Leo YS, Lye DC, Lin RT, Maurer-Stroh S, Lee B, Wang CI, Renia L, Ng LF. Lee CY, et al. Clin Transl Immunology. 2021 Feb 22;10(2):e1241. doi: 10.1002/cti2.1241. eCollection 2021. Clin Transl Immunology. 2021. PMID: 33628442 Free PMC article.
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.
Le Bert N, Clapham HE, Tan AT, Chia WN, Tham CYL, Lim JM, Kunasegaran K, Tan LWL, Dutertre CA, Shankar N, Lim JME, Sun LJ, Zahari M, Tun ZM, Kumar V, Lim BL, Lim SH, Chia A, Tan YJ, Tambyah PA, Kalimuddin S, Lye D, Low JGH, Wang LF, Wan WY, Hsu LY, Bertoletti A, Tam CC. Le Bert N, et al. J Exp Med. 2021 May 3;218(5):e20202617. doi: 10.1084/jem.20202617. J Exp Med. 2021. PMID: 33646265 Free PMC article. Clinical Trial.
Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore.
Puah SH, Young BE, Chia PY, Ho VK, Loh J, Gokhale RS, Tan SY, Sewa DW, Kalimuddin S, Tan CK, Pada SKMS, Cove ME, Chai LYA, Parthasarathy P, Ho BCH, Ng JJ, Ling LM, Abisheganaden JA, Lee VJM, Tan CH, Lin RTP, Leo YS, Lye DC, Yeo TW; Singapore 2019 novel coronavirus outbreak research team. Puah SH, et al. Sci Rep. 2021 Apr 5;11(1):7477. doi: 10.1038/s41598-021-81377-3. Sci Rep. 2021. PMID: 33820944 Free PMC article.
252 results