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Synthesis and Antiviral Activity of Novel β-D-N4-Hydroxycytidine Ester Prodrugs as Potential Compounds for the Treatment of SARS-CoV-2 and Other Human Coronaviruses.
Darnotuk ES, Siniavin AE, Shastina NS, Luyksaar SI, Inshakova AM, Bondareva NE, Zolotov SA, Lubenec NL, Sheremet AB, Logunov DY, Zigangirova NA, Gushchin VA, Gintsburg AL. Darnotuk ES, et al. Among authors: luyksaar si. Pharmaceuticals (Basel). 2023 Dec 26;17(1):35. doi: 10.3390/ph17010035. Pharmaceuticals (Basel). 2023. PMID: 38256869 Free PMC article.
New conjugates based on N4-hydroxycytidine with more potent antiviral efficacy in vitro than EIDD-2801 against SARS-CoV-2 and other human coronaviruses.
Siniavin AE, Gushchin VA, Shastina NS, Darnotuk ES, Luyksaar SI, Russu LI, Inshakova AM, Shidlovskaya EV, Vasina DV, Kuznetsova NA, Savina DM, Zorkov ID, Dolzhikova IV, Sheremet AB, Logunov DY, Zigangirova NA, Gintsburg AL. Siniavin AE, et al. Among authors: luyksaar si. Antiviral Res. 2024 May;225:105871. doi: 10.1016/j.antiviral.2024.105871. Epub 2024 Mar 28. Antiviral Res. 2024. PMID: 38555022 Free article.
Fluorothiazinon inhibits the virulence factors of uropathogenic Escherichia coli involved in the development of urinary tract infection.
Koroleva EA, Soloveva AV, Morgunova EY, Kapotina LN, Luyksaar SI, Luyksaar SV, Bondareva NE, Nelubina SA, Lubenec NL, Zigangirova NA, Gintsburg AL. Koroleva EA, et al. Among authors: luyksaar si. J Antibiot (Tokyo). 2023 May;76(5):279-290. doi: 10.1038/s41429-023-00602-5. Epub 2023 Mar 15. J Antibiot (Tokyo). 2023. PMID: 36922636
Antiviral Activity of N1,N3-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of Concern.
Siniavin AE, Novikov MS, Gushchin VA, Terechov AA, Ivanov IA, Paramonova MP, Gureeva ES, Russu LI, Kuznetsova NA, Shidlovskaya EV, Luyksaar SI, Vasina DV, Zolotov SA, Zigangirova NA, Logunov DY, Gintsburg AL. Siniavin AE, et al. Among authors: luyksaar si. Int J Mol Sci. 2022 Sep 5;23(17):10171. doi: 10.3390/ijms231710171. Int J Mol Sci. 2022. PMID: 36077564 Free PMC article.
Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice.
Sheremet AB, Zigangirova NA, Zayakin ES, Luyksaar SI, Kapotina LN, Nesterenko LN, Kobets NV, Gintsburg AL. Sheremet AB, et al. Among authors: luyksaar si. Biomed Res Int. 2018 Sep 10;2018:5810767. doi: 10.1155/2018/5810767. eCollection 2018. Biomed Res Int. 2018. PMID: 30276212 Free PMC article.
A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones inhibits intracellular growth and persistence of Chlamydia trachomatis.
Zigangirova NA, Kost EA, Didenko LV, Kapotina LN, Zayakin ES, Luyksaar SI, Morgunova EY, Fedina ED, Artyukhova OA, Samorodov AV, Kobets NV. Zigangirova NA, et al. Among authors: luyksaar si. J Med Microbiol. 2016 Jan;65(1):91-98. doi: 10.1099/jmm.0.000189. J Med Microbiol. 2016. PMID: 26489840
11 results