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Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy.
Zorzopulos J, Opal SM, Hernando-Insúa A, Rodriguez JM, Elías F, Fló J, López RA, Chasseing NA, Lux-Lantos VA, Coronel MF, Franco R, Montaner AD, Horn DL. Zorzopulos J, et al. Among authors: lux lantos va. World J Stem Cells. 2017 Mar 26;9(3):45-67. doi: 10.4252/wjsc.v9.i3.45. World J Stem Cells. 2017. PMID: 28396715 Free PMC article. Review.
Oligodeoxynucleotide IMT504 induces a marked recovery in a streptozotocin-induced model of diabetes in rats: correlation with an early increase in the expression of nestin and neurogenin 3 progenitor cell markers.
Bianchi MS, Hernando-Insúa A, Chasseing NA, Rodríguez JM, Elías F, Lago N, Zorzopulos J, Libertun C, Montaner AD, Lux-Lantos VA. Bianchi MS, et al. Diabetologia. 2010 Jun;53(6):1184-9. doi: 10.1007/s00125-010-1694-z. Epub 2010 Mar 11. Diabetologia. 2010. PMID: 20221823
Proposed mechanisms for oligonucleotide IMT504 induced diabetes reversion in a mouse model of immunodependent diabetes.
Bianchi MS, Bianchi S, Hernado-Insúa A, Martinez LM, Lago N, Libertun C, Chasseing NA, Montaner AD, Lux-Lantos VA. Bianchi MS, et al. Among authors: lux lantos va. Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E380-95. doi: 10.1152/ajpendo.00104.2016. Epub 2016 Jun 21. Am J Physiol Endocrinol Metab. 2016. PMID: 27329801 Free article.
Oligonucleotide IMT504 Improves Glucose Metabolism and Controls Immune Cell Mediators in Female Diabetic NOD Mice.
Bianchi S, Martínez Allo VC, Massimino M, Lavignolle Heguy MDR, Borzone FR, Gomez Bustillo S, Chasseing NA, Libertun C, Montaner AD, Rabinovich GA, Toscano MA, Lux-Lantos VA, Bianchi MS. Bianchi S, et al. Among authors: lux lantos va. Nucleic Acid Ther. 2021 Apr;31(2):155-171. doi: 10.1089/nat.2020.0901. Epub 2020 Dec 21. Nucleic Acid Ther. 2021. PMID: 33347786
89 results