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Total Synthesis of α- and β-Amanitin.
Lutz C, Simon W, Werner-Simon S, Pahl A, Müller C. Lutz C, et al. Angew Chem Int Ed Engl. 2020 Jul 6;59(28):11390-11393. doi: 10.1002/anie.201914935. Epub 2020 Apr 28. Angew Chem Int Ed Engl. 2020. PMID: 32091645
HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells.
Figueroa-Vazquez V, Ko J, Breunig C, Baumann A, Giesen N, Pálfi A, Müller C, Lutz C, Hechler T, Kulke M, Müller-Tidow C, Krämer A, Goldschmidt H, Pahl A, Raab MS. Figueroa-Vazquez V, et al. Among authors: lutz c. Mol Cancer Ther. 2021 Feb;20(2):367-378. doi: 10.1158/1535-7163.MCT-20-0287. Epub 2020 Dec 9. Mol Cancer Ther. 2021. PMID: 33298585
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
Noll EM, Eisen C, Stenzinger A, Espinet E, Muckenhuber A, Klein C, Vogel V, Klaus B, Nadler W, Rösli C, Lutz C, Kulke M, Engelhardt J, Zickgraf FM, Espinosa O, Schlesner M, Jiang X, Kopp-Schneider A, Neuhaus P, Bahra M, Sinn BV, Eils R, Giese NA, Hackert T, Strobel O, Werner J, Büchler MW, Weichert W, Trumpp A, Sprick MR. Noll EM, et al. Among authors: lutz c. Nat Med. 2016 Mar;22(3):278-87. doi: 10.1038/nm.4038. Epub 2016 Feb 8. Nat Med. 2016. PMID: 26855150 Free PMC article.
Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.
Litzenburger UM, Opitz CA, Sahm F, Rauschenbach KJ, Trump S, Winter M, Ott M, Ochs K, Lutz C, Liu X, Anastasov N, Lehmann I, Höfer T, von Deimling A, Wick W, Platten M. Litzenburger UM, et al. Among authors: lutz c. Oncotarget. 2014 Feb 28;5(4):1038-51. doi: 10.18632/oncotarget.1637. Oncotarget. 2014. PMID: 24657910 Free PMC article.
Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R.
Opitz CA, Litzenburger UM, Lutz C, Lanz TV, Tritschler I, Köppel A, Tolosa E, Hoberg M, Anderl J, Aicher WK, Weller M, Wick W, Platten M. Opitz CA, et al. Among authors: lutz c. Stem Cells. 2009 Apr;27(4):909-19. doi: 10.1002/stem.7. Stem Cells. 2009. PMID: 19353519
645 results