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Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Chen PY, et al. Among authors: lutgens e. Nat Metab. 2019 Sep;1(9):912-926. doi: 10.1038/s42255-019-0102-3. Epub 2019 Aug 26. Nat Metab. 2019. PMID: 31572976 Free PMC article.
Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.
van den Berg SM, Seijkens TT, Kusters PJ, Beckers L, den Toom M, Smeets E, Levels J, de Winther MP, Lutgens E. van den Berg SM, et al. Among authors: lutgens e. FASEB J. 2016 May;30(5):1779-88. doi: 10.1096/fj.201500175. Epub 2016 Jan 26. FASEB J. 2016. PMID: 26813974
., Seijkens, T. T. P., Kusters, P. J. H., Beckers, L., den Toom, M., Smeets, E., Levels, J., de Winther, M. P. J., Lutgens, E. Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow....
., Seijkens, T. T. P., Kusters, P. J. H., Beckers, L., den Toom, M., Smeets, E., Levels, J., de Winther, M. P. J., Lutgens, …
Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.
Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Döring Y, et al. Among authors: lutgens e. Circulation. 2017 Jul 25;136(4):388-403. doi: 10.1161/CIRCULATIONAHA.117.027646. Epub 2017 Apr 27. Circulation. 2017. PMID: 28450349 Free PMC article.
Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.
Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E. Aarts SABM, et al. Among authors: lutgens e. J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9. J Neuroinflammation. 2017. PMID: 28494768 Free PMC article.
Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption.
Kusters P, Seijkens T, Bürger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E. Kusters P, et al. Among authors: lutgens e. Am J Pathol. 2017 Dec;187(12):2912-2919. doi: 10.1016/j.ajpath.2017.08.016. Epub 2017 Sep 19. Am J Pathol. 2017. PMID: 28935569 Free article.
CD40L Deficiency Protects Against Aneurysm Formation.
Kusters PJH, Seijkens TTP, Beckers L, Lievens D, Winkels H, de Waard V, Duijvestijn A, Lindquist Liljeqvist M, Roy J, Daugherty A, Newby A, Gerdes N, Lutgens E. Kusters PJH, et al. Among authors: lutgens e. Arterioscler Thromb Vasc Biol. 2018 May;38(5):1076-1085. doi: 10.1161/ATVBAHA.117.310640. Epub 2018 Mar 8. Arterioscler Thromb Vasc Biol. 2018. PMID: 29519940
240 results