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6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.
Semenov VE, Zueva IV, Mukhamedyarov MA, Lushchekina SV, Kharlamova AD, Petukhova EO, Mikhailov AS, Podyachev SN, Saifina LF, Petrov KA, Minnekhanova OA, Zobov VV, Nikolsky EE, Masson P, Reznik VS. Semenov VE, et al. Among authors: lushchekina sv. ChemMedChem. 2015 Nov;10(11):1863-74. doi: 10.1002/cmdc.201500334. Epub 2015 Sep 28. ChemMedChem. 2015. PMID: 26412714
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.
Makhaeva GF, Boltneva NP, Lushchekina SV, Serebryakova OG, Stupina TS, Terentiev AA, Serkov IV, Proshin AN, Bachurin SO, Richardson RJ. Makhaeva GF, et al. Among authors: lushchekina sv. Bioorg Med Chem. 2016 Mar 1;24(5):1050-62. doi: 10.1016/j.bmc.2016.01.031. Epub 2016 Jan 18. Bioorg Med Chem. 2016. PMID: 26827140
Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment.
Kharlamova AD, Lushchekina SV, Petrov KA, Kots ED, Nachon F, Villard-Wandhammer M, Zueva IV, Krejci E, Reznik VS, Zobov VV, Nikolsky EE, Masson P. Kharlamova AD, et al. Among authors: lushchekina sv. Biochem J. 2016 May 1;473(9):1225-36. doi: 10.1042/BCJ20160084. Epub 2016 Feb 29. Biochem J. 2016. PMID: 26929400
Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.
Shchegol'kov EV, Makhaeva GF, Boltneva NP, Lushchekina SV, Serebryakova OG, Rudakova EV, Kovaleva NV, Burgart YV, Saloutin VI, Chupakhin ON, Bachurin SO, Richardson RJ. Shchegol'kov EV, et al. Among authors: lushchekina sv. Bioorg Med Chem. 2017 Aug 1;25(15):3997-4007. doi: 10.1016/j.bmc.2017.05.045. Epub 2017 May 20. Bioorg Med Chem. 2017. PMID: 28578994
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.
Makhaeva GF, Lushchekina SV, Boltneva NP, Serebryakova OG, Rudakova EV, Ustyugov AA, Bachurin SO, Shchepochkin AV, Chupakhin ON, Charushin VN, Richardson RJ. Makhaeva GF, et al. Among authors: lushchekina sv. Bioorg Med Chem. 2017 Nov 1;25(21):5981-5994. doi: 10.1016/j.bmc.2017.09.028. Epub 2017 Sep 20. Bioorg Med Chem. 2017. PMID: 28986116
77 results